首页|Population pharmacokinetics of lamotrigine in Chinese children with epilepsy

Population pharmacokinetics of lamotrigine in Chinese children with epilepsy

扫码查看
原文链接
  • NETL
  • NSTL
  • 万方数据
  • 维普
Aim:To establish a population pharmacokinetics (PPK) model for lamotrigine (LTG) in Chinese children with epilepsy in order to formulate an individualized dosage guideline.Methods:LTG steady-state plasma concentration data from therapeutic drug monitoring (TDM) were collected retrospectively from 284 patients,with a total of 404 plasma drug concentrations.LTG concentrations were determined using a HPLC method.The patients were divided into 2 groups:PPK model group (n=116) and PPK valid group (n=168).A PPK model of LTG was established with NONMEM based on the data from PPK model group according to a one-compartment model with first order absorption and elimination.To validate the basic and final model,the plasma drug concentrations of the patients in PPK model group and PPK valid group were predicted by the two models.Results:The final regression model for LTG was as follows:CL (L/h)=1.01*(TBW/27.87)0.635*e-0.753*VPA*e0.868*CBZ*e0.633*PB,Vd (L)=16.7*(TBW/27.87).The final PPK model was demonstrated to be stable and effective in the prediction of serum LTG concentrations by an internal and external approach validation.Conclusion:A PPK model of LTG in Chinese children with epilepsy was successfully established with NONMEM.LTG concentrations can be predicted accurately by this model.The model may be very useful for establishing initial LTG dosage guidelines.

lamotrigineChinese childrenpopulation pharmacokineticsNONMEMepilepsy

Da-ke HE、Li WANG、Wei LU、Jiong QIN、Shen ZHANG、Ling LI、Jian-ming ZHANG、Wei-qun BAO、Xiao-qing SONG、Hai-tao LIU

展开 >

Department of Pediatrics,Peking University First Hospital,Beijing 100034,China

Department of Pediatrics,Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200092,China

School of Pharmaceutical Science,Peking University Health Science Center,Beijing 100191,China

Department of Neurology,Beijing Children's Hospital,Beijing 100045,China

Department of Pharmacy,Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200092 ,China

展开 >

This project was supported by the National Natural Science Foundation of China

81171630

2012

10.1038/aps.2012.118

中国药理学报(英文版)
中科院上海药物研究所

中国药理学报(英文版)

CSTPCDCSCDSCI
影响因子：0.926
ISSN：1671-4083
年,卷(期)：2012.33(11)
  • 10
  • 34