Antitumor effect of Ganoderma(Lingzhi) mediated by immunological mechanism and its clinical application
The anti-tumor effect of Ganoderma(Lingzhi) is closely related to immunoregulation. Based on our research and other references,this article discussed the antitumor effect of Ganoderma mediated by immunological mechanism, including promoting the function of mononuclear-macro?phages,and natural killers,promoting maturation and differentiation of dendritic cells,increasing its antigen presentation,activating lymphocytes and increasing cytotoxicity of cytotoxin T lymphocyte, promoting production of cytokines,inhibiting tumor escape from immune surveillance. Also, clinical studies with immunological indexes were reviewed.