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灵芝抗肿瘤作用的免疫学机制及其临床应用

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灵芝的抗肿瘤作用与其免疫调节作用密切相关。本文在我们的研究工作的基础上,结合国内外文献论述灵芝抗肿瘤作用的免疫学机制,包括灵芝促进单核巨噬细胞和自然杀伤细胞功能;促进树突状细胞成熟、分化和抗原提呈功能;活化淋巴细胞、增强细胞毒T细胞的功能及促进细胞因子的生成;抑制肿瘤细胞的免疫逃逸反应;以及灵芝免疫治疗的基础研究等。涉及免疫学指标的灵芝的临床研究结果也一并介绍。
Antitumor effect of Ganoderma(Lingzhi) mediated by immunological mechanism and its clinical application
The anti-tumor effect of Ganoderma(Lingzhi) is closely related to immunoregulation. Based on our research and other references,this article discussed the antitumor effect of Ganoderma mediated by immunological mechanism, including promoting the function of mononuclear-macro?phages,and natural killers,promoting maturation and differentiation of dendritic cells,increasing its antigen presentation,activating lymphocytes and increasing cytotoxicity of cytotoxin T lymphocyte, promoting production of cytokines,inhibiting tumor escape from immune surveillance. Also, clinical studies with immunological indexes were reviewed.

Ganodermapolysaccharidestumorantineoplastic agents,phytogenictumor escapetherapeutic uses

林志彬

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北京大学医学部基础医学院药理学系,北京 100191

灵芝属 多糖类 抗肿瘤药,植物 免疫调节 肿瘤逃逸 治疗应用

2015

中国药理学与毒理学杂志
军事医学科学院毒物药物研究所,中国药理学会,中国毒理学会

中国药理学与毒理学杂志

CSTPCDCSCD北大核心
影响因子:1.182
ISSN:1000-3002
年,卷(期):2015.(6)
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