首页|钙元素对挤压Mg-Zn-Mn合金的显微组织、耐蚀性、生物相容性及抗菌性能的影响

钙元素对挤压Mg-Zn-Mn合金的显微组织、耐蚀性、生物相容性及抗菌性能的影响

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为了寻找合适植入应用的可生物降解材料,采用半连续铸造和热挤压工艺制备Mg-6Zn-0.3Mn-xCa(x=0,0.2,0.5,质量分数)合金,用金相显微镜、扫描电子显微镜和拉伸试验研究Mg-6Zn-0.3Mn-xCa合金的显微组织和力学性能.结果表明,微量Ca元素的加入可以细化挤压态Mg-6Zn-0.3Mn合金的晶粒,提高其强度.当Ca添加量分别为0.2％和0.5％(质量分数)时,合金的晶粒尺寸由4.8μm分别细化到4.6和4.2μm.三种合金中,添加0.5％Ca的合金具有更好的综合力学性能,极限拉伸强度和伸长率分别为334 MPa和20.3％.此外,还对所研究合金的腐蚀行为、细胞活性和抗菌性能进行评价.随着Ca含量的增加,合金的耐蚀性降低,这主要是由于Ca2Mg6Zn3相的形成导致有效阴极活性位点的数量增加.L929细胞的细胞毒性评估显示:与Mg-6Zn-0.3Mn和Mg-6Zn-0.3Mn-0.2Ca合金相比,Mg-6Zn-0.3Mn-0.5Ca合金具有更好的细胞活性.由于金黄色葡萄球菌的理化和生物学特性,在骨修复过程中,合金的抗菌活性随着Ca含量的增加而增强.
Microstructure, anticorrosion, biocompatibility and antibacterial activities of extruded Mg-Zn-Mn strengthened with Ca
To find suitable biodegradable materials for implant applications, Mg-6Zn-0.3Mn-xCa (x=0, 0.2 and 0.5, wt.％) alloys were prepared by semi-continuous casting followed by hot-extrusion technique. The microstructure and mechanical properties of Mg-6Zn-0.3Mn-xCa alloys were investigated using the optical microscope, scanning electron microscope and tensile testing. Results indicated that minor Ca addition can slightly refine grains of the extruded Mg-6Zn-0.3Mn alloy and improve its strength. When 0.2 wt.％ and 0.5 wt.％ Ca were added, the grain sizes of the as-extruded alloys were refined from 4.8 to 4.6 and 4.2 μm, respectively. Of the three alloys studied, the alloy with 0.5 wt.％ Ca exhibits better combined mechanical properties with the ultimate tensile strength and elongation of 334 MPa and 20.3％. The corrosion behaviour, cell viability and antibacterial activities of alloys studied were also evaluated. Increasing Ca content deteriorates the corrosion resistance of alloys due to the increase of amount of effective cathodic sites caused by the formation of more Ca2Mg6Zn3 phases. Cytotoxicity evaluation with L929 cells shows higher cell viability of the Mg-6Zn-0.3Mn-0.5Ca alloy compared to Mg-6Zn-0.3Mn and Mg-6Zn-0.3Mn- 0.2Ca alloys. The antibacterial activity against Staphylococcus aureus is enhanced with increasing the Ca content due to its physicochemical and biological performance in bone repairing process.

magnesium alloybio-corrosionantibacterial activitiesmicrostructuremechanical properties

刘宝胜、曹苗苗、张跃忠、胡勇、宫长伟、侯利锋、卫英慧

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太原科技大学材料科学与工程学院,太原 030024

太原科技大学化学与生物工程学院,太原 030024

太原理工大学材料科学与工程学院,太原 030024

镁合金 生物腐蚀 抗菌活性 显微组织 力学性能

authors are grateful for the financial supports from the Natural Science Foundation of Shanxi Province, ChinaNational Natural Science Foundation of ChinaTransformation of Scientific and Technological Achievements Programs of Higher Education Institutions in Shanxi, China (TSTATransformation of Scientific and Technological Achievements Programs of Higher Education Institutions in Shanxi, China (TSTACentral Special Funds Guiding the Development of Local Science and Technology, China

201901D2113105207122720191102004201903D111008YDZX20181400002967

2021

10.1016/S1003-6326(21)65501-2

中国有色金属学报(英文版)
中国有色金属学会

中国有色金属学报(英文版)

CSTPCDCSCDSCI
影响因子：1.183
ISSN：1003-6326
年,卷(期)：2021.31(2)
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