首页|二氧化钛纳米管阵列在大肠杆菌不同生长阶段的抗菌机理

二氧化钛纳米管阵列在大肠杆菌不同生长阶段的抗菌机理

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为了明确二氧化钛纳米管(TNT)阵列在早期粘附阶段的抗菌行为,在抛光的商业纯钛(Ti)表面制备两种TNT阵列,并探究TNT阵列和模式菌(大肠杆菌)之间的相互作用机制.结果显示,TNT阵列具有明显的早期抗菌性能,且这种抗菌性能与TNT阵列的表面自由能以及纳米拓扑结构密切相关.TNT阵列的抗菌机理包括:(1)在迟缓期(0～2 h)抑制细菌初始粘附效应;(2)在对数期(4～12 h)抑制增殖和物理杀菌作用;(3)在稳定期(>12 h)可能由于TNT阵列表面细菌的过度生长而导致抗菌性能降低.
Different antibacterial mechanisms of titania nanotube arrays at various growth phases of E. coli
To clarify the antibacterial behavior at early adhesion, two titania nanotube (TNT) arrays were fabricated on polished commercially pure titanium (Ti), and the interaction mechanisms between TNT arrays and the model bacteria (Escherichia coli, E. coli) were investigated. The results show that TNT arrays exhibit a significant early antibacterial effect, which is highly related to the surface free energy and nano-topography. The underlying antibacterial mechanisms include: (1) the anti-initial-attachment effect at the lag phase (0−4 h); (2) the anti-proliferation and physical bactericidal effects at the logarithmic phase (4−12 h); (3) the reduced antimicrobial properties probably due to the overgrowth of bacteria on TNT arrays at the stationary phase (12 h and then).

titania nanotube arrayEscherichia coliantibacterial mechanismbacterial adhesionbacterial proliferation

姬晓伟、刘娉婷、唐金成、万常俊、阳燕、赵志立、赵大鹏

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湖南大学 生物学院,长沙 410082

中南大学 口腔健康研究湖南省重点实验室 湘雅口腔医院 湘雅口腔医学院,长沙 410008

南方科技大学 材料科学与工程系,深圳 518055

中南大学 湘雅二医院 口腔与颌面外科,长沙 410011

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二氧化钛纳米管阵列 大肠杆菌 抗菌机制 细菌粘附 细菌增殖

authors are grateful for the financial supports from the National Natural Science Foundation of Chinaauthors are grateful for the financial supports from the National Natural Science Foundation of Chinaauthors are grateful for the financial supports from the National Natural Science Foundation of ChinaInnovation-oriented Advanced Technology and Industrial Technology Program Project of Hunan Province,ChinaCentral South University Postgraduate Education and Teaching Reform Project,ChinaNatural Science Foundation of Hunan Province,ChinaFundamental Research Funds for the Central Universities of Central South University,China

5160410452171114817027092020SK20172020JGB1162020JJ4459CX20200267

2021

10.1016/S1003-6326(21)65767-9

中国有色金属学报(英文版)
中国有色金属学会

中国有色金属学报(英文版)

CSTPCDCSCDSCI
影响因子：1.183
ISSN：1003-6326
年,卷(期)：2021.31(12)
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