首页|Nb2C MXene薄膜眼部植入体的生物相容性

Nb2C MXene薄膜眼部植入体的生物相容性

扫码查看
原文链接
  • 万方数据
采用四氟硼酸(HBF4)与氢氟酸(HF)复合酸蚀刻和真空抽滤法制备Nb2C MXene薄膜.利用扫描电子显微镜(SEM)、原子力显微镜(AFM)和X射线光电子能谱(XPS)等方法表征Nb2C MXene的表面结构、性质和组成.通过体内和体外实验评价Nb2CMXene薄膜的生物相容性.结果表明,Nb2C MXene具有层状、微纳表面结构,表面富集大量羟基.相比于对照组,1 mg/mLNb2C MXene培养的结膜成纤维细胞增殖率达到72.15％(p＜0.05).Nb2C MXene的细胞毒性评估为0级(p＞0.05),其溶血率为0.38％(＜5％).Nb2C MXene薄膜降低兔眼组织的炎症和氧化应激反应,在不诱导纤维化的情况下促进伤口愈合,其微纳表面促进细胞的黏附和增殖,表现出良好的生物相容性.
Biocompatibility of Nb2C MXene film for ophthalmic implants
The Nb2C MXene film was prepared by tetrafluoroboric acid(HBF4)and hydrofluoric acid(HF)etching and vacuum extraction.The surface structure,properties,and composition of Nb2C MXene were characterized by scanning electron microscopy(SEM),atomic force microscopy(AFM),X-ray photoelectron spectroscopy(XPS),and other methods.The biocompatibility of Nb2C MXene film was evaluated by in vivo and in vitro experiments.The results show the layered,micro-nano surface structure of Nb2C MXene with abundant hydroxyl groups(—OH)on the surface.Compared with the control group,the proliferation rate of conjunctival fibroblasts cultured with 1 mg/mL Nb2C MXene is 72.15％(p＜0.05).The cytotoxicity of Nb2C MXene is Grade 0(p＞0.05),and the hemolysis rate is 0.38％(＜5％).The oxidative stress and inflammatory responses in rabbit ocular tissues are inhibited by Nb2C MXene film,which promotes wound healing without inducing fibrosis,and its micro-nano structure promotes cell adhesion and proliferation,demonstrating good biocompatibility.

Nb2C MXenebiocompatibilityoxidative stresscell proliferationophthalmic application

马巍、彭立、陈百华

展开 >

中南大学湘雅二医院眼科,长沙 410011

湖南省眼科临床研究中心,长沙 410011

中南大学湘雅医学院附属海口医院眼科,海口 570311

Nb2C MXene 生物相容性 氧化应激 细胞增殖 眼科应用

国家自然科学基金国家自然科学基金湖南省自然科学基金Health Commission of Hunan Province,ChinaNatural Science Foundation of Hainan Province,China

82171030818706782021JJ30925B202307026146821QN1005

2024

10.1016/S1003-6326(24)66495-2

中国有色金属学报(英文版)
中国有色金属学会

中国有色金属学报(英文版)

CSTPCD
影响因子：1.183
ISSN：1003-6326
年,卷(期)：2024.34(5)