The effect of cut-outs on deformation behaviors and energy absorption of 6063 aluminum with thin-walled structures will be investigated by quasi-static axial compression using WAW-E600 microcomputer controlled universal testing machine. The results show that the deformation mode of the aluminum extrusions is changed from Euler mode to Mixed mode after setting single line cut-outs on the specimen, and the energy absorption increases 26.78%. The deformation behavior is more stable and the peak force is lower than that of the complete sample during compression. The size and position of cutouts have very significant effects on axial collapse behaviors of aluminum thin-walled structure. The aluminum samples buckle under Euler mode with poor performance of deformation stability, loading force and energy absorption, because cut-outs locate in the middle of extrusions. Gradually changing size of cut-outs could leads that the compression behaviors become concertina mode. The aluminum extrusions collapse from top to bottom sequentially with steady load curve and excellent energy absorbing performance. Large cut-outs will introduce local buckling with shear deformation. The compression behavior is a new mode, which has stable load and successive collapse process. Based on the experimental data, the influence of cut-outs size on the critical force was studied. The relationship between critical force and inertia of the thin-walled structure was established by using linear regression.