Bioinformatics Analysis of Rabbit Hemorrhagic Disease Virus Type 2 VP60 gene
In April 2020,the first case of rabbit distemper type 2 virus detected in Sichuan Province,the strain quickly spread in China.The VP60 gene is the main structural protein encoding the viral capsid protein of RH-DV2,involved in the rep-lication,assembly,and release processes of the virus.Therefore,this study isolated RH-DV2 from a rabbit farm and sequenced the VP60 gene for bioinformatics analysis.The homology between the FJ fenli RHDV2-VP60 gene and the RHDV2-VP60 reference sequence ranged from 95.7％to 99.4％,and the ho-mology with the RHDV-VP60 reference sequence ranged from 81.6％to 82.5％.The VP60 protein was mainly composed of hydrophobic amino acids,with a secondary structure of α-The proportion of spirals is 8.98％,β-Folding accounts for 30.22％,β-Corners account for 6.22％,irregular curly structures account for 54.58％,with 3 transmem-brane segments and 30 antigen sites,the maximum antigen site score is 1.213.This study is of great significance for understanding the biological characteristics and pathogenic mechanism of RHDV2,and provides a preliminary theoretical basis for the prevention and control of this disease.
rabbit hemorrhagic disease virus type 2VP60 genebioinformatics analysis
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