Protective Effect of Resveratrol on AFB1 Induced Damage to Spleen and Thymus of Rabbits
This study was to explore the protective effects of resveratrol(Res)on the spleen and thymus of rabbits with aflatoxin B1(AFB1)toxicity.Twenty-one 40-day-old rabbits were randomly divided into 3 groups:control group,AFB1,and Res+AFB1.The control group was fed a basal diet,the AFB1 group was fed a diet containing 0.3 mg/kg AFB1,and the Res+AFB1 group was fed a diet containing 0.3 mg/kg AFB1 and 30 mg/kg Res for 21 days.The numbers of immune cells in plasma were detected.Spleen and thymus tissues were collected to make paraffin sections for H.E.and PAS staining observation.Antioxidant indexes in spleen and thymus tissues were al-so determined.The results showed that Res significantly increased GSH-Px,SOD,T-AOC(P<0.05)and de-creased MDA(P<0.05)in the spleen and thymus of AFB1-damaged rabbits,and restored the tissue structures.Additionally,Res reversed the AFB1-induced changes in white blood cell,lymphocyte,neutrophil and monocyte counts,restoring immune function.These findings indicate that 30 mg/kg Res can alleviate AFB1-induced struc-tural damage in rabbit spleen and thymus,enhance antioxidant capacity and improve immune function.
resveratrolAFB1spleenthymusoxidative stressimmune function