人绒毛膜促性腺激素联合吡格列酮治疗多囊卵巢综合征的疗效
Efficacy of Human Chorionic Gonadotropin combined with Pioglitazone in the Treatment of Polycystic Ovary Syndrome
钱长明 1杨瑞 1常丽丽 1李慧慧1
作者信息
- 1. 深圳市萨米医疗中心(深圳市第四人民医院)妇产科,广东深圳 518118
- 折叠
摘要
目的 探讨吡格列酮联合人绒毛膜促性腺激素(HCG)治疗多囊卵巢综合征(PCOS)的疗效.方法 采取2021年1 月至 2022 年 3 月深圳市萨米医疗中心收治的PCOS患者 110 例作为研究对象,随机分为对照组和观察组,各 55 例.对照组采用吡格列酮治疗,观察组联用HCG.比较两组卵巢改善情况、血清性激素水平、卵巢血流动力学改善情况、不良反应发生率及随访 1 年内患者自然妊娠率及流产发生率.结果 治疗后,两组卵巢体积缩小,卵泡数量减少,最大卵泡直径提高,且观察组变化幅度更大,差异有统计学意义(P＜0.05);治疗后,两组血清黄体生成素(LH)、抗苗勒管激素(AMH)水平降低,雌激素(E2)、卵泡刺激素(FSH)水平升高,且观察组变化幅度更大,差异有统计学意义(P＜0.05);治疗后,两组卵巢动脉血流收缩期峰值流速(PSV)、舒张末期血流速(EDV)降低,搏动指数(PI)值升高,且观察组卵巢动脉血流PSV、PI和EDV明显优于对照组,差异有统计学意义(P＜0.05);两组不良反应发生率比较差异无统计学意义(P＞0.05);随访 1 年内,观察组自然妊娠率高于对照组,自然流产率低于对照组,差异有统计学意义(P＜0.05).结论 吡格列酮联合HCG治疗PCOS临床效果显著,能明显改善血清性激素水平和卵巢血流动力学,从而促进排卵,提高患者自然妊娠率,降低流产发生率.
Abstract
Objective To explore the efficacy of pioglitazone combined with human chorionic gonadotropin(HCG)in the treatment of polycystic ovary syndrome(PCOS).Methods A total of 110 PCOS patients admitted to Sami Medical Center in Shenzhen from January 2021 to March 2022 were selected as the study objects and randomly divided into control group and observation group,with 55 cases in each group.The control group was treated with pioglitazone,and the observation group was treated with HCG.Ovarian improvement,serum sex hormone level,ovarian hemodynamic improvement,incidence of adverse reactions,spontaneous pregnancy rate and abortion rate within 1 year of follow-up were compared between the two groups.Results After treatment,the ovarian volume decreased,the number of follicles decreased,and the maximum follicle diameter increased in the two groups,and the change range was greater in the observation group,the difference was statistically significant(P＜0.05).After treatment,the serum levels of luteinizing hormone(LH)and anti-Mullerian hormone(AMH)were decreased,while the levels of estrogen(E2)and follicle-stimulating hormone(FSH)were increased in the two groups,and the change range was greater in the observation group,the difference was statistically significant(P＜0.05).After treatment,the peak systolic flow velocity(PSV)and end-diastolic flow velocity(EDV)of ovarian artery in the two groups were decreased,and the pulse index(PI)was increased,and the PSV,PI and EDV of ovarian artery in the observation group were significantly better than those in the control group,the difference was statistically significant(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Within 1 year of follow-up,the spontaneous pregnancy rate in the observation group was higher than that in the control group,and the spontaneous abortion rate was lower than that in the control group,with statistical significance(P＜0.05).Conclusion The clinical effect of pioglitazone combined with HCG in the treatment of polycystic ovary syndrome is significant,which can significantly improve the serum sex hormone level and ovarian hemodynamics,thus promoting ovulation,increasing the natural pregnancy rate of patients,and reducing the incidence of abortion.
关键词
吡格列酮/人绒毛膜促性腺激素/多囊卵巢综合征/临床疗效Key words
Pioglitazone/Human chorionic gonadotropin/Polycystic ovary syndrome/Clinical effect引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据