摘要
目的 探讨子宫内膜异位症患者接受腹腔镜手术联合促性腺激素释放激素激动剂(GnRh-a)治疗的效果.方法 选取 2020 年 1 月至 2022 年 12 月十堰市茅箭区人民医院收治的 93 例子宫内膜异位症患者作为研究对象,按照随机数字表法分为观察组(n=48 例)和对照组(n=45 例).对照组接受腹腔镜手术联合孕三烯酮口服治疗,观察组接受腹腔镜手术联合GnRh-a皮下注射治疗,比较两组治疗有效率、复发情况、不良反应发生率、促黄体生成素、卵泡刺激素、雌二醇、癌胚抗原125、视觉模拟评分法(VAS)评分及骨密度.结果 观察组和对照组治疗有效率分别为93.75%和88.89%,差异无统计学意义(P＞0.05);观察组不良反应发生率为31.25%,明显高于对照组的11.11%(P＜0.05);观察组和对照组复发率分别为 6.25%和 8.89%,差异无统计学意义(P＞0.05).治疗前两组患者促黄体生成素、卵泡刺激素、雌二醇、癌胚抗原 125水平比较差异无统计学意义(P＞0.05);治疗后两组促黄体生成素、卵泡刺激素、雌二醇水平均明显降低(P＜0.05),且观察组明显低于对照组(P＜0.05),两组癌胚抗原 125 水平比较差异无统计学意义(P＞0.05).治疗前两组VAS评分及骨密度比较差异无统计学意义(P＞0.05);治疗后两组VAS评分及骨密度均明显降低(P＜0.05),但组间比较差异无统计学意义(P＞0.05).结论 子宫内膜异位症患者接受腹腔镜手术治疗后皮下注射GnRh-a效果较好,可有效改善体内激素水平.
Abstract
Objective To explore the effect of Laparoscopy combined with Gonadotropin-releasing hormone agonist(GnRh-a)in the treatment of Endometriosis.Methods A total of 93 patients with endometriosis treated in Maojian District People's Hospital of Shiyan City from January 2020 to December 2022 were selected as the study objects,and divided into observation group(n=48 cases)and control group(n=45 cases)according to random number table method.The control group received laparoscopic surgery combined with oral gestrenone treatment,and the observation group received laparoscopic surgery combined with subcutaneous GnRh-a treatment.The treatment effectiveness,recurrence,incidence of adverse reactions,luteinizing hormone,follicle stimulating hormone,estradiol,carcinoma embryo antigen 125,visual analog scale(VAS)score and bone mineral density of the two groups were compared.Results The effective rate of treatment in observation group and control group was 93.75%and 88.89%,respectively,with no statistical significance(P＞0.05).The incidence of adverse reactions in observation group was 31.25%,which was significantly higher than that in control group(11.11%)(P＜0.05).The recurrence rates of observation group and control group were 6.25%and 8.89%,respectively,with no statistical significance(P＞0.05).There was no significant difference in the levels of luteinizing hormone,follicle stimulating hormone,estradiol and carcinoembryonic antigen 125 between two groups before treatment(P＞0.05).After treatment,the levels of luteinizing hormone,follicle stimulating hormone and estradiol in both groups were significantly decreased(P＜0.05),and the observation group was significantly lower than the control group(P＜0.05);There was no statistical significance in the level of carcinoembryonic antigen 125 between the two groups(P＞0.05).There was no significant difference in VAS score and bone mineral density between the two groups before treatment(P＞0.05).VAS score and bone mineral density were significantly decreased in both groups after treatment(P＜0.05),but there was no statistical significance between the two groups(P＞0.05).Conclusion The effect of subcutaneous injection of GnRh-a after Laparoscopy in patients with Endometriosis is good,which can improve the hormone level in the body.
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