卡介苗治疗中高危非肌层浸润性膀胱癌复发时间与不良反应的关系
Relationship between Recurrence Time and Adverse Reactions in High-risk Non-muscular Invasive Bladder Cancer Treated with BCG Vaccine
曹恺 1刘川 1杨俊杰2
作者信息
- 1. 重庆医科大学附属第二医院泌尿外科,重庆 400010
- 2. 重庆市沙坪坝区陈家桥医院泌尿外科,重庆 400038
- 折叠
摘要
目的 探讨中高危非肌层浸润性膀胱癌(NMIBC)患者行卡介苗(BCG)膀胱灌注治疗的复发时间与不良反应之间的关系.方法 选取 2018 年 6 月至 2021 年 6 月重庆医科大学附属第二医院泌尿外科收治的接受BCG膀胱灌注的 550例中高危NMIBC患者作为研究对象,分析BCG膀胱灌注的复发时间与不良反应之间的关系.结果 550 例BCG膀胱灌注治疗患者中,86例未出现不良反应,随访12个月,发现1年无复发生存率为82.18%(452/550),累计复发率为17.82%(98/550).局部不良反应患者与全身不良反应患者复发时间比较差异无统计学意义(t=0.359,P=0.360).发生 2 级不良反应患者复发时间短于发生 1 级不良反应患者,差异有统计学意义(t=7.501,P<0.05).发生 1 种及以下不良反应患者复发时间与发生两种不良反应患者复发时间比较差异无统计学意义(P>0.05),但发生 3 种及以上不良反应患者复发时间明显短于以上两组,差异有统计学意义(P<0.05).结论 BCG膀胱灌注治疗的复发时间与患者不良反应分级、数量有着一定的联系,随着不良反应分级与数量的上升,NMIBC的复发时间越短.
Abstract
Objective To analyze the relationship between time to recurrence and adverse reactions in patients with medium-to high-risk non-muscle-invasive bladder cancer(NMIBC)treated with BCG bladder perfusion.Methods A total of 550 patients with moderate and high-risk NMIBC who received BCG bladder perfusion admitted to the Department of Urology,the Second Affiliated Hospital of Chongqing Medical University from June 2018 to June 2021 were selected as the study objects to analyze the recurrence time,adverse reactions,the relationship between the recurrence time and adverse reactions.Results Of the 550 patients treated with BCG bladder instillation,86 patients did not experience adverse reactions.12 months of follow-up revealed a 1-year recurrence-free survival rate of 82.18%(452/550)and a cumulative recurrence rate of 17.82%(98/550).There was no statistically significant difference in the time to relapse between patients with local adverse reactions and those with systemic adverse reactions(t=0.359,P=0.360).time to relapse was lower in patients with Grade 2 adverse reactions than in patients with Grade 1 adverse reactions and the difference was statistically significant(t=7.501,P<0.05).There was no statistically significant difference between the time to recurrence of 1 or less adverse reactions and the time to recurrence of 2 adverse reactions(P>0.05),but the time to recurrence in patients with 3 or more adverse reactions was significantly lower than the above two groups,and the difference was statistically significant(P<0.05).Conclusion The time to recurrence of BCG bladder perfusion treatment is related to the grading and number of adverse reactions of patients,and the shorter the time to recurrence of NMIBC as the grading and number of adverse reactions rise.
关键词
卡介苗/中高危非肌层浸润性膀胱癌/复发时间/不良反应Key words
Bacillus calmette guerin/Medium-to high-risk non-muscle invasive bladder cancer/Time to recurrence/Adverse reactions引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据