康妇消炎栓和阿奇霉素序贯联合治疗急性盆腔炎对炎症反应与免疫功能及安全性的影响
Effects of Kangfu Xiaoyan Suppository and Azithromycin Sequential Combination Therapy on Inflammatory Response,Immune Function,and Safety in Acute Pelvic Inflammation
孟康1
作者信息
- 1. 泰安市妇幼保健院药剂科,山东泰安 271000
- 折叠
摘要
目的 探讨急性盆腔炎患者采用康妇消炎栓联合阿奇霉素序贯治疗对其免疫功能、炎症反应、安全性的影响.方法 选取2020 年10 月至2022 年10 月泰安市妇幼保健院收治的急性盆腔炎患者 80 例作为研究对象,依据随机数字表法分为对照组和观察组,每组40 例.对照组予以阿奇霉素序贯治疗,观察组采用康妇消炎栓联合阿奇霉素序贯治疗.比较两组患者治疗前后炎症因子[白细胞介素1β(IL-1β)、C反应蛋(CRP)、干扰素γ(IFN-γ)]、免疫功能指标[CD4+、CD8+、CD4+/CD8+],记录两组患者不良反应(呕吐恶心、嗜睡、头晕)发生情况.结果 治疗后,观察组IL-1β、CRP、IFN-γ水平低于对照组,差异有统计学意义(P<0.05);治疗后,观察组 CD4+、CD8+、CD4+/CD8+改善效果优于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率5.00%低于对照组的 20.00%,差异有统计学意义(P<0.05).结论 急性盆腔炎患者采用康妇消炎栓联合阿奇霉素序贯治疗可有效减轻炎症反应,增强免疫功能,减少不良反应.
Abstract
Objective To explore the effects of Kangfu Xiaoyan suppository combined with Azithromycin sequential treatment on immune function,inflammatory response,and safety in patients with acute pelvic inflammatory disease.Methods Eighty patients with acute pelvic inflammatory disease admitted to Tai'an Maternal and Child Health Hospital from October 2020 to October 2022 were selected as the study objects,and were divided into control group and observation group according to random number table method,with 40 cases in each group.The control group was given sequential treatment with azithromycin,and the observation group was given sequential treatment with azithromycin combined with Kangfu Xiaoyan suppositant.Inflammatory factors[interleukin 1β(IL-1β),C-reactive egg(CRP),interferon γ(IFN-γ)]and immune function indicators[CD4+,CD8+,CD4+/CD8+]were compared between the two groups before and after treatment,and adverse reactions(vomiting,nausea,lethargy,dizziness)were recorded between the two groups.Results After treatment,the levels of IL-1β,CRP and IFN-γ in observation group were lower than those in control group,and the differences were statistically significant(P<0.05).After treatment,the improvement effect of CD4+,CD8+ and CD4+/CD8+ in observation group was better than that in control group,the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 5.00%lower than that in the control group(20.00%),with statistical significance(P<0.05).Conclusion Kangfu Xiaoyan suppository combined with Azithromycin sequential treatment can effectively reduce inflammation,enhance immune function and reduce adverse reactions in patients with acute pelvic inflammatory disease.
关键词
急性盆腔炎/康妇消炎栓/阿奇霉素/序贯治疗/免疫功能/炎症反应/安全性Key words
Acute pelvic inflammatory disease/Kangfu Xiaoyan suppository/Azithromycin/Sequential treatment/Immunity/Inflammatory response/Security引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据