两种剂量羟考酮注射液对胆囊切除手术患者血流动力学及术后不良反应的影响
Effects of Two Doses of Oxycodone Injection on Hemodynamics and Postoperative Adverse Reactions in Patients undergoing Cholecystectomy
刘建 1李华 1蒋海1
作者信息
- 1. 前海人寿广州总医院麻醉科,广州 511325
- 折叠
摘要
目的 探讨在胆囊切除手术中0.08 mg/kg和0.12 mg/kg两种剂量的羟考酮注射液复合丙泊酚对患者血流动力学和术后不良反应发生率的影响.方法 选取 2021 年 3 月至 2022 年 6 月前海人寿广州总医院收治的 117 例行腹腔镜下胆囊切除术患者作为研究对象,根据羟考酮使用剂量不同分为A组(n=63)和B组(n=54).两组均行羟考酮注射液复合丙泊酚麻醉,A组羟考酮注射液用量0.08 mg/kg,B组用量0.12 mg/kg,比较两组的麻醉效果和术后不良反应发生率.结果 A组苏醒质量评分、视觉模拟评分法(VAS)评分高于B组,苏醒时间、拔管时间和肛门排气时间短于B组,但组间比较差异无统计学意义(P＞0.05).A组术后24 h的肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)水平低于B组,差异有统计学意义(P＜0.05).两组术前及术后24 h的血栓素A2、血浆内皮素水平比较差异无统计学意义(P＞0.05).A组术后即刻及苏醒后10 min的血氧饱和度(SpO2)、平均动脉压及心率均低于B组,差异有统计学意义(P＜0.05).A组不良反应发生率低于B组,差异有统计学意义(P＜0.05).结论 0.08 mg/kg和0.12 mg/kg两种剂量的羟考酮注射液复合丙泊酚在腹腔镜下胆囊切除术中均能取得良好的麻醉效果,但0.08 mg/kg剂量对患者血流动力学影响较小且能够降低术后不良反应发生率.
Abstract
Objective To explore the effects of two doses of oxycodone injection(0.08 mg/kg and 0.12 mg/kg)combined with propofol on hemodynamics and incidence of postoperative adverse reactions in patients undergoing cholecystectomy.Methods A total of 117 patients undergoing laparoscopic cholecystectomy admitted to Guangzhou General Hospital of Foresea Life Insurance from March 2021 to June 2022 were selected as the study objects,and were divided into group A(n=63)and group B(n=54)according to different doses of hydroxycodone.Both groups were given oxycodone injection combined with propofol anesthesia,the dosage of oxycodone injection in group A was 0.08 mg/kg,and the dosage of oxycodone injection in group B was 0.12 mg/kg.The anesthetic effect and incidence of postoperative adverse reactions were compared between the two groups.Results The score of resuscitation quality and visual analogue scale(VAS)in group A was higher than that in group B,and the time of resuscitation,extubation and anal exhaust was shorter than that in group B,but there was no statistical significance between groups(P＞0.05).The levels of tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)in group A were lower than those in group B 24 h after operation,and the differences were statistically significant(P＜0.05).There were no significant differences in thromboxane A2 and plasma endothelin levels between the two groups during and after extubation(P＞0.05).The blood oxygen saturation(SpO2),mean arterial pressure and heart rate of group B immediately after surgery and 10 min after recovery were lower than those of group A,and the differences were statistically significant(P＜0.05).The incidence of adverse reactions in postoperative recovery stage in group A was lower than that in group B,and the difference was statistically significant(P＜0.05).Conclusion Both 0.08 mg/kg and 0.12 mg/kg of oxycodone injection combined with propofol can achieve good anesthetic effect in laparoscopic cholecystectomy,but 0.08 mg/kg of oxycodone injection has little effect on hemodynamics of patients and can reduce the postoperative adverse reaction rate.
关键词
胆囊切除术/羟考酮/丙泊酚/血流动力学/不良反应Key words
Cholecystectomy/Oxycodone/Propofol/Hemodynamics/Adverse reactions引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据