氨氯地平联合阿托伐他汀对老年高血压患者的血脂及炎症反应的影响
Effect of Amlodipine combined With Atorvastatin on Blood Lipid and Inflammatory Response in Patients with Hypertension
刘芬辉1
作者信息
- 1. 广州市花都区第二人民医院药剂科,广州 510850
- 折叠
摘要
目的 探讨氨氯地平联合阿托伐他汀对老年高血压患者的血脂及炎症反应的影响.方法 选取2021 年5 月至2022年5 月广州市花都区第二人民医院收治的100 例高血压患者作为研究对象,随机分为对照组与观察组,各50 例.对照组予以苯磺酸氨氯地平片,观察组在对照组基础上联合阿托伐他汀钙片治疗.比较两组患者血压、血脂、炎症因子水平、治疗有效率及不良反应.结果 用药后两组舒张压及收缩压水平降低,且观察组低于对照组,差异有统计学意义(P＜0.05);用药后,两组三酰甘油、总胆固醇、低密度脂蛋白胆固醇水平低于用药前,高密度脂蛋白胆固醇水平高于用药前,且观察组改善幅度优于对照组,差异有统计学意义(P＜0.05);用药后两组肿瘤坏死因子-α、白细胞介素-6、超敏C反应蛋白降低,且观察组低于对照组,差异有统计学意义(P＜0.05);观察组治疗有效率高于对照组(P＜0.05);观察组不良反应发生率与对照组比较差异无统计学意义(P＞0.05).结论 将阿托伐他汀及氨氯地平应用于高血压患者治疗中,能够降低血压和改善血脂水平,缓解机体炎症反应状态,提升治疗效果,不良反应少,安全性高.
Abstract
Objective To explore the effects of amlodipine combined with atorvastatin on blood lipids and inflammation in elderly patients with hypertension.Methods A total of 100 patients with hypertension admitted to the Second People's Hospital of Huadu District,Guangzhou from May 2021 to May 2022 were selected as the study objects and randomly divided into control group and observation group,with 50 cases in each group.Control group was given amlodipine besylate tablet,observation group was combined with atorvastatin calcium tablet on the basis of control group.Blood pressure,blood lipids,levels of inflammatory factors,treatment effectiveness and adverse reactions were compared between the two groups.Results After treatment,the diastolic and systolic blood pressure levels of the two groups were decreased,and the observation group was lower than the control group,the difference was statistically significant(P＜0.05).After treatment,the levels of triglyceride,total cholesterol and low density lipoprotein cholesterol in 2 groups were lower than before treatment,and the level of high density lipoprotein cholesterol were higher than before treatment,and the improvement of observation group was better than that in control group,the difference was statistically significant(P＜0.05).After treatment,tumor necrosis factor-α,interleukin-6 and hypersensitive C-reactive protein were decreased in two groups,and observation group was lower than control group,the difference was statistically significant(P＜0.05).The effective rate of the observation group was higher than that of the control group(P＜0.05).There was no significant difference in the incidence of adverse reactions between the observation group and the control group(P＞0.05).Conclusion The application of atorvastatin and amlodipine in the treatment of hypertensive patients can reduce blood pressure and improve blood lipid levels,alleviate the inflammatory response state of the body,improve the therapeutic effect,less adverse reactions,and high safety.
关键词
炎症反应/血脂/高血压/阿托伐他汀/氨氯地平/血压Key words
Inflammatory response/Blood lipid/High blood pressure/Atorvastatin/Amlodipine/Blood pressure引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据