裸花紫珠联合抗菌药物治疗细菌感染性疾病的有效性和安全性系统评价
Meta-analysis of Callicarpae Nudiflorae combined with Antibiotics in Treatment of Bacterial Infectious Disease
傅健英 1蔡晓东 1马小花 1王升勇 1刘春瑶 1陈凡1
作者信息
- 1. 海南卫生健康职业学院药学系,海口 571000
- 折叠
摘要
目的 系统评价裸花紫珠联合抗菌药物治疗细菌感染性疾病的有效性与安全性,以期为中药与抗菌药物联合应用的合理性提供循证依据.方法 计算机检索PubMed、Embase、Cochrane、中国期刊全文数据库、中文期刊全文数据库、万方数据知识服务平台中相关文献(检索时限均为建库截至2022年5月20日),并应用RevMan 5.3软件对纳入研究进行Meta分析.结果 共纳入23 篇文献,Meta分析结果显示试验组(裸花紫珠与抗菌药物联合使用)的治疗有效率[RR=1.20,95%CI(1.14～1.26),P＜0.000 01]、退热时间[MD=-2.13,95%CI(-3.45～-0.80),P=0.002]、白细胞(WBC)水平[MD=0.77,95%CI(0.01～1.52),P=0.05]、降钙素原(PCT)水平[MD=1.14,95%CI(0.50～1.78),P=0.000 5]、C反应蛋白(CRP)水平[MD=1.44,95%CI(0.91～1.97),P＜0.000 01]、白细胞介素-6(IL-6)水平[MD=0.97,95%CI(0.04～1.90),P=0.04]等方面均优于对照组(单用抗菌药物).其中有14 篇报道了不良反应的结局指标,Meta分析结果显示试验组与对照组不良反应发生率比较差异无统计学意义[RR=0.91,95%CI(0.58～1.43),P=0.69].结论 裸花紫珠联合抗菌药物可显著提高治疗细菌感染性疾病的总有效率,缩短发热时间,降低WBC、PCT、CRP、IL-6 水平,且两组的不良反应发生率无明显差异.
Abstract
Objective To evaluate the effectiveness and safety of callicarpae nudiflorae combined with antibiotics in treatment of bacterial infectious disease,in order to provide basis for evidence-based in the rationality of the combination.Methods PubMed,EMBase,Cochrane library,CNKI,VIP and Wanfang database were researched from inception to May 2022.Meta-analysis was performed by using RevMan 5.3 software.Results A total of 23 clinical controlled trials were included.Meta-analysis showed that total response rate[RR=1.20,95%CI(1.14～1.26),P＜0.000 01],antipyretic time[MD=-2.13,95%CI(-3.45～-0.80),P=0.002],WBC[MD=0.77,95%CI(0.01～1.52),P=0.05],PCT[MD=1.14,95%CI(0.50～1.78),P=0.000 5],CRP[MD=1.44,95%CI(0.91～1.97),P＜0.000 01],IL-6[MD=0.97,95%CI(0.04～1.90),P=0.04]of experiment group were better than those of control group.Fourteen trials were included outcome indicators of adverse reactions.From the results of meta-analysis,experiment group was same to the control group in the incidence of adverse drug reaction without statistical difference[RR=0.91,95%CI(0.58～1.43),P=0.69].Conclusion The combined antibacterial drugs can significantly improve the total effective rate of the treatment of bacterial infectious diseases,shorten the fever time,and reduce the levels of WBC,PCT,CRP and IL-6,and there is no significant difference in the incidence of adverse reactions between the two groups.
关键词
裸花紫珠/抗菌药物/细菌感染性疾病/Meta分析Key words
Callicarpae nudiflorae/Antibiotics/Bacterial infectious disease/Meta-analysis引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据