摘要
本文总结了近年来国内外温针灸治疗类风湿关节炎(RA)的机制研究文献,结果显示,温针灸治疗RA是多靶点、多途径共同作用的结果,主要通过调控相关信号通路(转录激活蛋白 1(STAT1)/核因子(NF)-κB 信号通路、Rho 相关蛋白激酶(ROCK)/单丝氨酸蛋白激酶 1(LIMK1)/Cofilin 信号通路)、调节细胞因子(白细胞介素 1β(IL-1β)、白细胞介素6(IL-6)、白细胞介素17(IL-17)、肿瘤坏死因子-α(TNF-α)、金属基质蛋白酶(MMP)等)表达、调节免疫平衡(体液和细胞免疫的动态平衡)、调节骨代谢平衡、调控微小RNA(miRNAs)表达等多种机制直接或间接地改善关节及滑膜炎症反应、组织内环境、血管翳,防止软骨和软骨下骨的破坏起到治疗RA的作用.
Abstract
This paper summarizes the literatures on the mechanism of warm acupuncture and moxibustion in the treatment of rheumatoid arthritis(RA)at home and abroad in recent years.The results show that the treatment of RA by warm acupuncture and moxibustion is the result of the joint action of multiple targets and multiple pathways.Mainly through regulating related signaling pathways(transcription activation protein 1(STAT1)/nuclear factor(NF)-κB signaling pathway,RHO-associated protein kinase(ROCK)/monofiline protein kinase 1(LIMK1)/Cofilin signaling pathway),regulating cytokine(interleukin 1β(IL-1β),interleukin 6(IL-6),interleukin-17(IL-17),tumor necrosis factor-α(TNF-α),metallomatrix proteinase(MMP))expression,regulating immune balance(the dynamic balance of humoral and cellular immunity),regulating bone metabolism balance,regulating miRNAs expression and other mechanisms,it directly or indirectly improves the inflammatory response of joints and synovitis,the internal environment of tissues,the vascular opacity,and prevents the destruction of cartilage and subchondral bone.
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