首页|某院围术期预防应用质子泵抑制剂合理性及成本-效果分析

某院围术期预防应用质子泵抑制剂合理性及成本-效果分析

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  • 国家科技期刊平台
  • NETL
  • NSTL
  • 万方数据
目的 调查某院围术期预防性应用质子泵抑制剂(PPIs)的现状，对其使用合理性进行分析，并探究不同用药方案的成本-效果，评估药物经济学评价。方法 抽取克拉玛依市中西医结合医院手术科室病区 2022 年 1-12 月归档病历，筛选围术期预防应用PPIs病例，汇总使用情况并评价用药合理性。根据药物选择分为A、B、C 3 组，A组采用注射用奥美拉唑钠预防，B组采用注射用兰索拉唑预防，C组采用注射用泮托拉唑钠预防。比较不同PPIs用药方案预防应激性溃疡(SU)有效率、药物不良反应发生率及成本-效果情况。结果 共387 份病历围术期预防应用PPIs，其中具备指征患者272 例，115例存在无指征用药。3 组患者预防SU有效率、药物不良反应发生率比较差异无统计学意义(P＞0。05)。A、B、C 3 组预防用药方案中，A组的C/E最低，C组次之，B组最高。与A组方案比较，B组方案每增加 1 单位疗效，PPIs预防用药成本增加14。72 元;C组方案每增加1 单位疗效，PPIs预防用药成本增加6。96 元。结论 该院围术期预防性应用PPIs存在不合理情况，需采取相应措施改进，选择奥美拉唑预防SU是一种有效、经济的方案。
Rationality and Cost-effectiveness Analysis of Perioperative Prophylactic Application for Proton Pump Inhibitors in A Hospital
Objective To investigate the current situation of perioperative prophylactic use of proton pump inhibitors(PPIs)in a hospital,analyze the rationality of its use,explore the cost-effectiveness of different drug regimens,and evaluate the pharmacoeconomics.Methods The archival medical records of the surgical department of Karamay Hospital of Integrated Chinese and Western Medicine from January to December 2022 were selected to screen perioperative prophylactic application of PPIs,summarize the use situation and evaluate the rationality of drug use.Groups A,B and C were divided into three groups according to drug selection.Group A was prophylaxis with omeprazole sodium for injection,group B was prophylaxis with lansoprazole sodium for injection,and group C was prophylaxis with Pantoprazole sodium for injection.The incidence of prevention of stress ulcer(SU),incidence of adverse drug reactions and cost-effectiveness of different PPIs were compared.Results A total of 387 medical records were used for perioperative prophylactic use of PPIs,including 272 patients with indications and 115 patients with drugs without reference.There was no significant difference in the incidence of SU,the incidence of adverse drug reactions and the effective rate of SU prevention among 3 groups(P＞0.05).In group A,B and C,the C/E of group A was the lowest,followed by group C,and group B was the highest.Compared with group A,the cost of prophylactic PPIs in group B increased by 14.72 yuan for every 1 unit increase in efficacy.In group C,the cost of prophylactic PPIs increased by 6.96 yuan for each additional unit of efficacy.Conclusion The prophylactic application of PPIs during perioperative period in our hospital is unreasonable,and corresponding measures should be taken to improve it.Omeprazole is an effective and economical scheme to prevent SU.

Proton pump inhibitorsPerioperative periodPreventive medicationRationalityCost-effectiveness analysis

施洋、谭雪、陈振东、彭磊、周娜、柳俊宇、易兵荣、樊登峰

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克拉玛依市中西医结合医院药剂科,新疆克拉玛依 834000

克拉玛依市中西医结合医院五官科,新疆克拉玛依 834000

克拉玛依市中西医结合医院普外科,新疆克拉玛依 834000

克拉玛依市中西医结合医院呼吸科,新疆克拉玛依 834000

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质子泵抑制剂 围术期 预防用药 合理性 成本-效果分析

克拉玛依市首届科技创新人才培养项目克拉玛依市创新环境建设计划(软科学)项目克拉玛依市中西医结合医院(市人民医院)院级科研项目

克科发[2023]1号2024hjrkx0040Kzxy2023003

2024

10.12010/j.issn.1673-5846.2024.06.005

中国药物经济学
中国中医药研究促进会

中国药物经济学

影响因子：0.712
ISSN：1673-5846
年,卷(期)：2024.19(6)