Efficacy of Liraglutide and Dagliprazin combined with Metformin in Newly Diagnosed Overweight/obese Patients with Type 2 Diabetes Mellitus
Objective To explore the effect of liraglutide and dagliprazin combined with metformin in newly diagnosed overweight/obese patients with type 2 diabetes mellitus(T2DM).Methods A total of 127 T2DM patients admitted to the People's Hospital of Hechi City from January 2022 to June 2023 were selected as the study objects,and were divided into Liraglutide group(n=62)and Dagliaglizin group(n=65)according to different treatment plans.The liraglutide group was given liraglutide combined with metformin,and dagliprazin group was given dagliprazin combined with metformin.The waist circumference(WC),body mass index(BMI),systolic blood pressure(SBP),diastolic blood pressure(DBP),fasting blood glucose(FPG),glycosylated hemoglobin(HbA1C),total cholesterol(TC),triglyceride(TG),blood uric acid(SUA),urinary microalbumin/creatinine ratio(UACR),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C)and adverse reactions were compared between two groups.Results After treatment,WC,BMI,SBP and DBP in both groups were significantly improved compared with those before treatment(P＜0.05).WC and BMI in Liraglutide group were lower than those in Daglipzin group(P＜0.05),SBP and DBP in liraglutide group were higher than those in Daglipzin group(P＜0.05).After treatment,there were no significant differences in FPG,HbA1C,TG,SUA,UACR and HDL-C between the two groups(P＞0.05),but the levels of TC and LDL-C in Liraglutide group were lower than those in dagliprazin group(P＜0.05).The incidence of nausea and vomiting in Liraglutide group was higher than that in dagliprazin group(P＜0.05),and the incidence of ketosis and urogenital tract infection was lower than that in Dagliprazin group(P＜0.05).Conclusion For newly diagnosed overweight/obese T2DM patients,liraglutide and dagliprazin combined with metformin can effectively control blood glucose,liraglutide can reduce WC and BMI,and dagliprazin is more conducive to lowering blood pressure.Liraglutide was more likely to cause adverse reactions in the upper digestive tract,and dagliprazin was more likely to induce ketosis and urogenital tract infection.
Type 2 diabetes mellitusNewly diagnosedDagliprazinLiraglutideObese
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