The Relationship Between Serum Angiopoietin 2 and Granuloprotein precursor Levels and Prognosis in Elderly Patients with Severe Pneumonia and Respiratory Failure
Objective To explore the relationship between serum angiopoietin 2(Ang-2)and granuloprotein precursor(PGRN)and prognosis of elderly patients with severe pneumonia complicated with respiratory failure.Methods A total of 291 patients with severe pneumonia combined with respiratory failure admitted to the Northern Theater Command General Hospital from January 2021 to December 2022 were selected as the study objects.2 patients with missing case data were excluded,and a total of 289 patients were included.According to the clinical outcome at 28 days,the patients were divided into survival group(234 cases)and death group(55 cases).Logistic regression analysis was performed to analyze the influencing factors of death in elderly patients with severe pneumonia complicated with respiratory failure.Results There were significant differences in gender,age,body mass index(BMI),acute physiology and Chronic Health status Scoring System Ⅱ(APACHEⅡ)score,hypertension,diabetes,white blood cell count,neutrophil count,lymphocyte count,Ang-2 and PGRN between survival group and death group(P＜0.05).Before treatment,there was significant difference in serum Ang-2 level between survival group and death group(P＜0.05),but no significant difference in serum PGRN level(P＞0.05).With the progress of treatment,the difference of Ang-2 level increased gradually,and the Ang-2 level in survival group was significantly lower than that in death group on day 1,7 and 28 after treatment(P＜0.05).The level of PGRN in the survival group was significantly lower than that in the death group on day 1,7 and 28 after treatment(P＜0.05).The main risk factors for death in elderly patients with severe pneumonia combined with respiratory failure included age,hypertension,diabetes,white blood cell count,neutrophil count,APACHEⅡ score,Ang-2 level,and PGRN.ROC curve analysis showed that pre-treatment serum Ang-2 levels showed a high sensitivity of 0.75 and a relatively good specificity of 0.68 in predicting survival.The AUC area is 0.81.The sensitivity of serum PGRN level before treatment was slightly lower(0.62),but the specificity was 0.72 and the AUC area was 0.799.Conclusion Serum Ang-2 and PGRN are associated with the prognosis of severe pneumonia in elderly patients with respiratory failure,and monitoring their levels has important clinical significance for disease diagnosis,treatment,and prognosis.
Angiopoietin 2Granular protein precursorSevere pneumoniaRespiratory failure
国家科技期刊平台
NSTL
万方数据
