阿替普酶静脉溶栓联合依达拉奉对老年急性脑梗死患者疗效及炎症因子与氧化应激因子的影响
Efficacy of Intravenous Thrombolysis combined with Edaravone in Elderly Patients with Acute Cerebral Infarction and Its Effect on Inflammatory Factors and Oxidative Stress Factors
孔顺利 1马彦红1
作者信息
- 1. 济宁市兖州区人民医院神经内科,山东济宁 272100
- 折叠
摘要
目的 探讨阿替普酶静脉溶栓联合依达拉奉对老年急性脑梗死患者疗效及炎症因子、氧化应激因子的影响.方法 选取 2020 年 1 月至 2022 年 5 月济宁市兖州区人民医院收治的 120 例急性脑梗死患者作为研究对象,随机分为观察组与对照组,各 60 例.对照组予以阿替普酶溶栓,观察组采用阿替普酶溶栓+依达拉奉治疗.比较两组神经功能、认知功能、炎症因子及氧化应激因子水平.结果 治疗前,两组美国国立卫生研究院卒中量表(NIHSS)、简易智能精神状态检查量表(MMSE)评分比较差异无统计学意义(P＞0.05);治疗后,两组NIHSS评分降低,且观察组低于对照组,两组MMSE评分升高,且观察组高于对照组,差异有统计学意义(P＜0.05);治疗前,两组超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)水平比较差异无统计学意义(P＞0.05);治疗后,两组hs-CRP、IL-6 水平降低,且观察组低于对照组,差异有统计学意义(P＜0.05);治疗前,两组谷胱甘肽过氧化物酶(GSH-Px)、丙二醛(MDA)、超氧化物歧化酶(SOD)水平比较差异无统计学意义(P＞0.05);治疗后,两组GSH-Px、SOD水平升高,且观察组高于对照组,两组MDA水平降低,且观察组低于对照组,差异有统计学意义(P＜0.05).结论 采用阿替普酶静脉溶栓联合依达拉奉治疗急性脑梗死,能显著改善神经、认知功能情况,其作用机制可能与减轻机体炎症反应及氧化应激状况有关.
Abstract
Objective To explore the efficacy of intravenous thrombolysis combined with Edaravone in elderly patients with acute cerebral infarction and its effect on inflammatory factors and oxidative stress factors.Methods A total of 120 patients with acute cerebral infarction admitted to Yanzhou District People's Hospital of Jining City from January 2020 to May 2022 were selected as the study objects and randomly divided into observation group and control group,with 60 cases in each group.The control group was treated with alteplase thrombolysis,and the observation group was treated with alteplase thrombolysis plus edaravone.The levels of neurological function,cognitive function,inflammatory factors and oxidative stress factors were compared between the two groups.Results Before treatment,there was no significant difference in National Institutes of Health Stroke Scale(NIHSS)and Simple Intelligent Mental State Examination Scale(MMSE)scores between the two groups(P＞0.05).After treatment,NIHSS score decreased in both groups,and the observation group was lower than the control group,and MMSE score increased in both groups,and the observation group was higher than the control group,the difference was statistically significant(P＜0.05).Before treatment,there was no significant difference in hypersensitive C-reactive protein(hs-CRP)and interleukin-6(IL-6)levels between the two groups(P＞0.05).After treatment,the levels of hs-CRP and IL-6 in two groups were decreased,and the observation group was lower than the control group,the difference was statistically significant(P＜0.05).Before treatment,there was no significant difference in glutathione peroxidase(GSH-Px),malondialdehyde(MDA)and superoxide dismutase(SOD)levels between the two groups(P＞0.05).After treatment,the levels of GSH-Px and SOD in the two groups were increased,and the observation group was higher than the control group,and the MDA level in the two groups was decreased,and the observation group was lower than the control group,the difference was statistically significant(P＜0.05).Conclusion For patients with acute cerebral infarction,the combination of alteplase thrombolytic therapy and edaravone can significantly improve the neurological and cognitive functions,the mechanism of which may be related to the alleviation of inflammation and oxidative stress in the body.
关键词
阿替普酶/静脉溶栓/依达拉奉/老年/急性脑梗死/疗效/认知功能Key words
Alteplase/Intravenous thrombolysis/Edaravone/Elderly/Acute cerebral infarction/Curative effect/Cognitive function引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据