沙丁胺醇联合布地奈德雾化吸入治疗小儿哮喘合并呼吸道病毒感染的疗效及对炎症反应的影响
Efficacy of Salbutamol combined with Budesonide Nebulized Inhalation in the Treatment of Infantile Asthma with Respiratory Virus Infection and Its Influence on Inflammation
王维芳1
作者信息
- 1. 临沂市妇幼保健院药学部,山东 临沂 276000
- 折叠
摘要
目的 探讨沙丁胺醇联合布地奈德雾化吸入治疗小儿哮喘合并呼吸道病毒感染的疗效及对炎症反应的影响.方法 选取2018年12月至2020年12月临沂市妇幼保健院收治的小儿哮喘合并呼吸道病毒感染患儿120例作为研究对象,按随机数字表法分为对照组与观察组,各60 例.对照组给予常规治疗联合沙丁胺醇治疗,观察组加用布地奈德治疗,比较两组临床疗效、症状改善时间、肺功能、炎症反应以及随访情况.结果 与对照组比较,观察组治疗有效率较高,哮鸣音消失时间、气促缓解时间、喘憋缓解时间、发热缓解时间及咳嗽缓解时间均较短,差异有统计学意义(P＜0.05).与对照组比较,观察组治疗后肺功能指标第一秒钟用力呼气容积(FEV1)、呼气流速峰值(PEFR)及用力肺活量(FVC)较高,炎症因子C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)均较低,差异有统计学意义(P＜0.05).随访 6 个月期间观察组上呼吸道感染次数、哮喘发作次数少于对照组,差异有统计学意义(P＜0.05).结论 沙丁胺醇联合布地奈德雾化吸入治疗小儿哮喘合并呼吸道病毒感染可有效改善患儿临床症状及体征,加快疾病康复速度,提高肺功能,减轻炎症反应,短期随访情况较好.
Abstract
Objective To explore the effect of salbutamol combined with budesonide nebulized inhalation in the treatment of childhood asthma with respiratory virus infection and their influence on inflammation.Methods 120 children with asthma complicated with respiratory virus infection admitted to Linyi maternal and Child Health Hospital of Shandong Province from December 2018 to December 2020 were selected as the study subjects.They were divided into control group and observation group according to the random number table method,with 60 cases each.The control group was treated with routine therapy combined with salbutamol,and the observation group was treated with budesonide.The clinical efficacy,symptom improvement time,lung function,inflammatory reaction and follow-up were compared between the two groups.Results Compared with the control group,in the observation group the effective rate of treatment was higher,and the disappearance time of wheezing sound,the remission time of shortness of breath,the remission time of wheezing and suffocation,the remission time of fever and the remission time of cough were shorter(P＜0.05).Compared with the control group,in the observation group after treatment the first second forced expiratory volume(FEV1),peak expiratory flow rate(PEFR)and forced vital capacity(FVC)were higher,and the inflammatory reaction indexes C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),the levels of interleukin-6(IL-6)and interleukin-8(IL-8)were significantly lower(P＜0.05).During the follow-up period of 6 months,the number of upper respiratory tract infections and asthma attacks in the observation group were less than that in the control group(P＜0.05).Conclusion Salbutamol combined with budesonide nebulized inhalation treatment of children with asthma combined with respiratory virus infection can better improve the clinical symptoms and signs of the patients,speed up the recovery of the disease,promote the improvement of lung function,and reduce the inflammation.The short-term follow-up is better.
关键词
沙丁胺醇/布地奈德/小儿哮喘/呼吸道病毒感染/疗效/炎症反应Key words
Salbutamol/Budesonide/Pediatric asthma/Respiratory virus infection/Curative effect/Inflammatory response引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据