Pharmacoeconomics Evaluation of Compound Glycyrrhizin:Collected,Non-collected and Imported in the Treatment of Chemotherapy Induced Liver Injury
Objective To evaluate the economic effects of collected,non-collected and imported glycyrrhizin in the treatment of chemotherapy liver injury.Methods A retrospective analysis was conducted on the medical records of hospitalized patients with non-small cell lung cancer diagnosed at the First Hospital of Jilin University from May 2021 to May 2023,who developed liver injury after chemotherapy.The patients were divided into three groups based on the use of chemotherapy related DILI drugs,Group A consisting of 39 patients used centralized purchasing of compound glycyrrhetinic acid glycosides,while Group B of 47 patients relied on non-centralized purchasing of compound glycyrrhetinic acid glycosides,and another 41 patients in Group C used imported compound glycyrrhetinic acid glycosides.Taking the clinical treatment efficiency as the effect index,a decision tree model was established to analyze the cost-effectiveness and sensitivity of three compound glycyrrhizin in the treatment of chemotherapy-related DILI.Results Cost-effectiveness analysis showed that the cost-effectiveness ratio(C/E)of the three groups were 0.40 in group A,3.80 in group B and 4.27 in group C,respectively,with the smallest in group A and the largest in group C.There was no statistical significance in the comparison of treatment effectiveness among the three groups,and the incremental cost-effectiveness ratio was not needed to be calculated,so the treatment plan of group A was more economical.The results of sensitivity analysis are basically consistent with those of cost-effectiveness analysis,which indicates that the results of cost-effectiveness analysis are reliable.Conclusion Centralized,non-centralized and imported compound glycyrrhetinic acid glycosides in the treatment of chemotherapy related DILI,collected compound glycyrrhetinic acid glycosides has more cost-effective advantages.
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