甲基苯丙胺诱导程序性细胞死亡机制的研究进展
Advances in the mechanism of methamphetamine-induced programmed cell death
李雄 1杨根梦 1严赫 1丁佳萌 1洪仕君 1张冬先1
作者信息
- 1. 国家卫生健康委员会毒品依赖和戒治重点实验室,昆明医科大学法医学院,昆明 650500
- 折叠
摘要
甲基苯丙胺(methamphetamine,METH)属于苯丙胺类药物中的一种精神兴奋剂,是非法药物使用者最常滥用的药物之一.滥用METH具有很强的神经毒性及药物依赖性,而其神经毒性与细胞程序性死亡密切相关,如细胞凋亡(apoptosis)、坏死性凋亡(necroptosis)、自噬(autophagy)、焦亡(pyroptosis)、铁死亡(ferroptosis).本文就 METH滥用诱导细胞程序性死亡的机制进行综述,希望有助于后续研究METH滥用引起的神经损伤的潜在治疗靶点,为METH的戒断与干预治疗提供参考和依据.
Abstract
Methamphetamine(METH)is a psychostimulant in the amphetamine group of drugs and is one of the most commonly abused substances by illicit drug users.Methamphetamine abuse is highly neurotoxic and drug-dependent,and its neurotoxicity is closely related to programmed cells death,such as apoptosis,necroptosis,autophagy,pyroptosis,and ferroptosis.This paper provides an overview of the mechanisms of how methamphetamine addiction induces programmed cell death,hoping to contribute to the subsequent study of potential therapeutic targets of neurological damage induced by methamphetamine abuse,and to provide references and rationale for the treatment of methamphetamine withdrawal and intervention.
关键词
甲基苯丙胺/凋亡/坏死性凋亡/自噬/焦亡/铁死亡Key words
methamphetamine/apoptosis/necroptosis/autophagy/pyroptosis/ferroptosis引用本文复制引用
基金项目
云南省科技厅项目(202301AY070001-262)
云南省教育厅项目(2023Y0617)
出版年
2024
NETL
NSTL
万方数据