新冠康复者认知损害特征及影响因素分析
Characteristics and risk factors of cognitive impairment among COVID-19 survivors
赵逸苗 1姜振东 2倪舒羽 1曾娜 1闫薇 3师乐 3张立国 2罗晓玉 2伍珊珊 2夏雯雨 2吴萍 4时杰 4鲍彦平 1陆林5
作者信息
- 1. 北京大学公共卫生学院,北京 100191;北京大学中国药物依赖性研究所,药物依赖性研究北京市重点实验室,北京 100191
- 2. 武汉科技大学附属武汉市武昌医院,武汉 430063
- 3. 北京大学第六医院,北京大学精神卫生研究所,国家卫生健康委员会精神卫生学重点实验室(北京大学),国家精神心理疾病临床医学研究中心,北京 100191
- 4. 北京大学中国药物依赖性研究所,药物依赖性研究北京市重点实验室,北京 100191
- 5. 北京大学第六医院,北京大学精神卫生研究所,国家卫生健康委员会精神卫生学重点实验室(北京大学),国家精神心理疾病临床医学研究中心,北京 100191;北京大学前沿交叉科学研究院,北大-清华生命联合中心,北京 100191
- 折叠
摘要
目的 了解新冠康复人群长期认知损害特征并分析影响因素.方法 自2021年10月至11月对武汉市某区2020年感染新冠的康复者进行调查,通过客观评估的蒙特利尔认知评估量表(Montreal Cognitive Assessment,MoCA)和主观报告的认知失败问卷(Cognitive Failures Questionnaire-14,CFQ-14)全面评价新冠康复者认知损害情况,并采用Logistic回归进行影响因素分析.结果 本研究共纳入1000份有效问卷,其中轻型、普通型、重型/危重型分别有 875 人(87.50％)、40 人(4.00％)、85 人(8.50％),平均年龄为 55.86±13.84 岁,55.40％是女性,38.81％为本科及以上学历.新冠康复者中认知损害的比例为15.60％.影响因素分析发现,年龄大于60岁、低学历、急性期诊断为重型或危重型、伴有多个自我报告症状、伴有焦虑和PTSD症状的康复者更容易发生认知损害.结论 新冠感染20个月后,仍有近1/6的康复者存在认知损害,高龄、低学历、急性期病情严重、伴有更多的躯体和精神心理症状的康复者更容易发生认知损害,需要对该重点人群长期随访并进行针对性干预.
Abstract
Objective To explore long-term characteristics and risk factors of cognitive impairment among COVID-19 survivors.Methods A survey was conducted among survivors infected with COVID-19 in 2020 from Oct.2021 to Nov.2021 in a district of Wuhan.Cognitive function was measured by objective evaluation via the Montreal Cognitive Assessment(MoCA)and subjective evaluation via the Cognitive Failures Questionnaire-14(CFQ-14).Risk factors relative to cognitive impairment were analyzed by logistic regression analysis.Results A total of 1000 survivors with a mean(SD)age of 55.86(13.84)years and 55.40％women were included.38.81％of survivors had a bachelor's degree or higher.Moreover,15.60％of COVID-19 survivors had cognitive impairment.Factors associated with cognitive impairment were older than 60 years,low education,severe acute illness,with more self-reported symptoms,and with anxiety and PTSD symptoms.Conclusion 20 months after recovery,nearly one-sixth of COVID-19 survivors had cognitive impairment.The elderly,those with low educational background,severe illness in the acute phase,and more physical and mental symptoms were more prone to cognitive impairment.Long-term follow-up and targeted intervention were needed for this key population.
关键词
新型冠状病毒/流行病学调查/认知损害/危险因素Key words
COVID-19/epidemiological investigation/cognitive impairment/risk factors引用本文复制引用
基金项目
北京市自然科学基金新冠专项(M23013)
国家重点研发计划(2021YFC0863700)
国家自然科学基金面上项目(82171514)
出版年
2024
NETL
NSTL
万方数据