基于互联网的认知行为干预联合双背侧前额叶低频重复经颅磁刺激治疗酒精依赖患者的临床研究
The effect of Internet-based cognitive behavioral intervention combined with low-frequency repetitive transcranial magnetic stimulation targeting the double dorsal prefrontal cortex on alcohol-dependent patients
冯枫 1徐杰 2孙沛 3李洁 4程晓东 1徐莉莎1
作者信息
- 1. 宿州市第二人民医院,安徽宿州 234000
- 2. 北京高新医院,北京 100021;清华大学心理学系,北京 100084;天津医科大学精神卫生与心理学系,天津 300070
- 3. 清华大学心理学系,北京 100084
- 4. 清华大学医学院,北京 100084
- 折叠
摘要
目的 探究基于互联网的认知行为干预联合双背侧前额叶低频重复经颅磁刺激对酒精依赖患者的临床价值.方法 收集2022年1月1日到2023年6月1日在宿州市第二人民医院就诊的确诊酒精依赖患者80例,根据治疗方法不同分为观察组和对照组,各40例.对照组给予对症治疗,观察组在对照组基础上给予基于互联网的认知行为干预联合双背侧前额叶低频重复经颅磁刺激治疗,比较两组治疗前后酒精依赖程度、戒断反应、负性情绪、认知功能变化情况,记录两组复饮及不良反应发生情况.结果 两组患者治疗前MAST评分、CIWA-Ar评分、SAS评分、SDS评分、MoCA评分无统计学差异(P＞0.05),治疗后两组MAST评分、CIWA-Ar评分、SAS评分、SDS评分均明显降低(P＜0.05),MoCA评分明显增加(P＜0.05),且观察组(P＜0.05)更低(P＜0.05),观察组MoCA评分更高,随访6个月观察组复饮率为5.00％(2/40),低于对照组的17.50％(7/40),差异有统计学意义(x2=6.221,P=0.020).两组患者在治疗过程中均未发生明显不良反应.结论 基于互联网的认知行为干预联合双背侧前额叶低频重复经颅磁刺激治疗能减轻酒精依赖程度和改善戒断反应,能有效改善焦虑抑郁情绪,提高认知功能,降低复饮率.
Abstract
Objective To explore the clinical value of Internet-based cognitive behavioral intervention combined with low-frequency repetitive transcranial magnetic stimulation(rTMS)of bilateral dorsal prefrontal cortex in patients with alcohol dependence.Methods A total of 80 patients with confirmed alcohol dependence treated in our department from January 1,2022 to June 1,2023,who were collected and divided into observation group and control group according to different treatment methods,40 cases in each group.The control group received symptomatic treatment,while the observation group received Internet-based cognitive behavioral intervention combined with low-frequency repetitive transcranial magnetic stimulation targeting the bilateral dorsal prefrontal cortex in addition to the treatment given to the control group.The degree of alcohol dependence,withdrawal reaction,negative emotions,and changes in cognitive function were compared between the two groups before and after treatment.Additionally,the relapse of drinking and adverse reactions were recorded.Results There was no significant difference in MAST,CIWA-Ar,SAS,SDS,and MoCA scores between the two groups before treatment(P＞0.05).After treatment,the MAST,CIWA-Ar,SAS,and SDS scores in both groups were significantly decreased(P＜0.05),while the MoCA score was significantly increased(P＜0.05).The observation group showed lower MAST,CIWA-Ar,SAS,and SDS scores(P＜0.05)and a higher MoCA score(P＜0.05)compared to the control group.The relapse rate of the observation group was 5.00％(2/40),which was lower than the 17.50％(7/40)of the control group(x2=6.221,P=0.020).No significant adverse reactions occurred in either group during treatment.Conclusion Internet-based cognitive behavioral intervention combined with low-frequency repetitive transcranial magnetic stimulation targeting the bilateral dorsal prefrontal cortex can reduce the degree of alcohol dependence and improve withdrawal symptoms,effectively alleviate anxiety and depression,enhance cognitive function,and reduce the relapse rate.
关键词
酒精依赖/双背侧前额叶/低频重复经颅磁刺激/互联网/认知行为治疗Key words
alcohol dependence/bilateral dorsal prefrontal lobes/low frequency repetitive transcranial magnetic stimulation/the Internet/cognitive behavioral therapy引用本文复制引用
基金项目
中国禁毒基金(中禁基合字[2016]22号)
出版年
2024
NETL
NSTL
万方数据