茶摄入量与抑郁障碍的因果关联:两样本孟德尔随机化研究
Causal association between tea intake and depressive disorder:A two-sample Mendelian randomization study
杜若南 1蔡海鹏 1杨可冰 1李伟 1王志仁 1赵荣江 1王鑫 1哈森其木格2
作者信息
- 1. 北京大学回龙观临床医学院/北京回龙观医院,北京 100096
- 2. 内蒙古自治区呼和浩特市第一医院老年科,呼和浩特 010000
- 折叠
摘要
目的 探究茶摄入量与抑郁障碍风险的因果关联.方法 使用茶摄入量相关的遗传变异数据作为工具变量,使用抑郁障碍的全基因组关联数据作为结局变量.采用逆方差加权法(IVW)作为孟德尔随机化(MR)的主要分析方法,并将MR-Egger等方法作为补充估计.结果 最终纳入41个SNPs进入分析,IVW分析结果显示OR=1.04,PIVW=0.54,即饮茶与抑郁障碍风险无明确因果关系.敏感性分析显示主要结果稳健,无离群值,MR-Presso检验得到了一致的关联效应估计.MR-Egger回归分析未发现潜在多效性.结论 本研究从遗传学角度未能提供饮茶降低抑郁障碍风险的证据.
Abstract
Objective To explore the causal association between tea intake and risk of depression.Methods A two-sample Mendelian randomization analysis was performed using Genome-wide Association Study(GWAS)summary data.Inverse variance weighted(IVW)was used as the primary estimate of Mendelian randomization(MR),with additional methods serving as supplementary estimates.Sensitivity analysis was conducted using the MR-PRESSO test and MR-Egger regression.Results Forty-one SNPs were eventually included in the analysis,and IVW analysis showed no clear causal relationship between tea intake and risk of depression(OR=1.04,PIVW=0.54).MR-PRESSO test provided consistent estimates of association effects.MR-Egger regression analysis did not find pleiotropy.Conclusion The present study failed to provide evidence that tea intake reduces the risk of depression from a genetic perspective.We therefore need more experimental studies in the future to elucidate the potential causal association between tea intake and the risk of depression.
关键词
茶摄入量/抑郁障碍/全基因组关联研究/孟德尔随机化/因果关系Key words
tea intake/depression/genome-wide association studies/Mendelian randomisation/causality引用本文复制引用
出版年
2024
NETL
NSTL
万方数据