泼尼松激活乙肝病毒致严重肝功能损害1例
One case of serious liver function damage induced by prednisone activating the hepatitis b virus
夏小凤 1谢彦兵 1李海兵1
作者信息
- 1. 解放军第184医院药械科，江西鹰潭 335000
- 折叠
摘要
1例58岁女性患者，既往有类风湿关节炎病史10余年，口服醋酸泼尼松片（5 mg，bid）10余年，此次因双膝关节疼痛加重2年余入院。入院查肝功能异常，给予保肝、退黄、抗病毒等治疗，总胆红素、直接胆红素持续性上升，皮肤巩膜重度黄染，并出现腹水。停用泼尼松，继续给予保肝、退黄、抗病毒、输注血浆、利尿等对症治疗，患者症状、肝功能等情况逐渐好转，于入院治疗66 d后出院。
Abstract
One 58-year-old female patient has previous history of rheumatoid arthritis for more than 10 years and has taken oral acetic acid throwing prednisone tablets (5 mg, bid) for more than 10 years. The patient was admitted to hospital mainly because pain of the knee joints had been aggravated for more than 2 years. The liver function of the patient was abnormal after admission, and the treatment of protecting liver function, retreating yellow, antivirus were given to the patient. And then the total bilirubin and direct bilirubin continued rising. Severe yellowing of the skin sclera and ascites occurred. The administration of prednisone was stopped and the continuous symptomatic treatment including antivirus, injection of plasma, diuresis were given to the patient. The symptoms and liver function of the patient gradually improved, and the patient discharged after the 66-day treatment.
关键词
泼尼松/肝损害/乙肝病毒再激活/药品不良反应Key words
Prednisone/Liver damage/HBV reactivation/Adverse drug reaction引用本文复制引用
出版年
2016
NETL
NSTL
维普
万方数据