Objective To investigate effect of high-dose polyethylene glycol(PEG)on infantile functional constipation(FC),growth and development in infants.Methods One hundred and thirty infants with FC admitted to our hospital from October 2022 to July 2023 were enrolled in this study and randomized into the control group and the experimental group with 65 in each.The in-fants in the control group were treated with lactulose oral solution,and those in the experimental group with high-dose PEG.Then the number of bowel movements,Bristol stool form scale,symptom relief,growth and development,clinical efficacy and incidence of adverse reactions were observed in both groups.Results The experimental group reported a larger number of bowel movements[(5.58±0.62)vs.(4.42±0.59)],higher Bristol stool form scale score[(3.53±1.15)vs.(2.63±1.02)],longer body height[(87.48±8.76)cm vs.(75.22±8.58)cm],higher body weight[(14.38±2.15)kg vs.(11.27±2.21)kg],better clinical efficacy rate(98.46%vs.89.23%),and lower scores on abdominal distension[(3.69±1.32)vs.(4.56±1.15)],painful stools[(2.11±2.10)vs.(3.78±2.09)],difficulty in defecation[(2.79±0.72)vs.(4.04±0.69)],and loss of appetite[(2.99±1.58)vs.(4.83±1.47)]as compared to the control.There were significant differences between the 2 groups(P<0.05).Conclusion Treatment of FC with high dose PEG can alleviate con-stipation,and improve growth and development in infants.
Infant functional constipationHigh-dose polyethylene glycolGrowth and developmentClinical effect
维普
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