Objective To explore the risk factors of liraglutide-induced gastrointestinal adverse reaction(GIAR),and establish a prediction model and verify the accuracy of it.Methods The information of 149 inpatients with type 2 diabetes who had been treated with liraglutide in the 909th Hospital/Dongnan Hospital of Xiamen University from July 2021 to September 2022 was retrospectively analyzed.In a ratio of 4:1,those patients were randomly divided into study group(119 cases)and verification group(30 cases).The clinical indexes of 119 patients in the study group were statistically analyzed,and the independent risk factors of GIAR induced by liraglutide were detected.Logistic model equation was transformed to establish combined predictors,and receiver operating characteristic(ROC)curve was used to determine the area under the curve(AUC)and optimal critical value of the combined predictors.Results Among 119 patients,28(23.53%)had GIAR.Multivariate logistic regression analysis showed that history of carsickness,combined α-glucosidase inhibitor(AGI)and sex were independent risk factors of GIAR induced by liraglutide.Logistic model equation was transformed into a calculation formula of the combined predictors(Ycombined predictors).Ycombined predictors = Xhistory of carsickness + 1.165Xcombined AGI + 3.285Xsex.The maximum AUC of the combined predictors was 0.741.The optimal critical value was 3.785 when the Youden index was the highest(0.376).The accuracy of the model was 76.67%with the clinical indexes of 30 patients in the verification group.Conclusion History of carsickness,combined AGI and sex were independent risk factors of GIAR induced by liraglutide.Combining the above three clinical indexes to establish the combined predictors had great predictive value for the risk of GIAR induced by liraglutide.
LiraglutideGastrointestinal adverse reactionRisk factorPrediction model
维普
万方数据
