Objective To research the correlation between CYP3A5 gene polymorphism and dose-releted concentration(C/D)of postoperative tacrolimus(FK506)of heart transplantation patients.Methods The databases of PubMed,Cochrane Library,Embase,Epub Ahead of Print,China National Knowledge Infrastructure(CNKI),WanFang Data Knowledge Service Platform(WanFang),Vip Chinese Science and Technology Journal Database(VIP)from database construction to November 2022 were searched and analyzed.All statistical analyses were performed with Rev Man 5.3 software.Results 7 researches with a total of 422 patients were finally included.The results showed that FK506 concentration was significantly higher in CYP3A5*3/*3 phenotype carriers than that in CYP3A5*1/*3 or CYP3A5*1/*1 phenotype carriers after heart transplantation(P<0.000 01).Additionally,the ethnic subgroup results showed that in the 1st,6th and 12th months after operation,CYP3A5*3/*3 phenotype significantly increased FK506 concentration in Caucasian,Asian and other ethnic subgroups.As for age subgroup analysis,higher concentrations of tacrolimus were found in adult patients with CYP3A5*3/*3 phenotype,while in children,the CYP3A5 gene polymorphism did not significantly affect the tacrolimus metabolism.Conclusion The present meta-analysis demonstrated that CYP3A5 genes could significantly affect FK506 concentration in heart transplantation patients,among whom CYP3A5*1/*1or CYP3A5*1/*3 gene carriers might need appropriately higher doses of tacrolimus to produce anti-rejection effect.
万方数据
维普
