A 69-year-old female patient received dabrafenib mesylate capsule(150 mg,po,bid)and trametinib tablets(2 mg,qd)for malignant melanoma on the left foot.On the second day after administration,she got a fever up to 39℃ without chills,which was considered as fever syndrome caused by drugs.Her body temperature returned to normal after being given ibuprofen capsule(400 mg,q 6 h)and stopping dabrafenib capsules for 24 h.Dalafenil capsules(75 mg,bid)was restarted and no obvious fever appeared.It is recommended to increase the dosage of dalafinil capsules to(150 mg,qd + 75 mg,qn)if tolerable.If the body temperature increases to more than 40℃ or is accompanied by obvious chills,it is recommended to stop drugs or prophylactically use steroids such as prednisone(7.5—25 mg·d-1)or dexamethasone(0.5—4 mg·d-1).If the fever does not improve,the dose of both drugs should be adjusted.It is usually recommended to reduce a dose gradient of the two drugs and the final dose of daberfenib and trametinib should not be less than(50 mg,bid)and(1.0 mg,qd),respectively.She didn't develop fever syndrome including high fever and chills again in the out-of-hospital follow up.
万方数据
维普
