Objective To investigate the effect of carbamazepine combined with diclofenac sodium on analgesia and mental status following surgery for traumatic brain injury.Methods Eighty-six patients with traumatic brain injuries who underwent surgical treatment in our hospital from May 2022 to June 2023 were selected and randomized into the observation group and control group,with 43 in each group.All patients required postoperative analgesic medication,and diclofenac sodium was given in the control group while diclofenac sodium combined with carbamazepine was administered.Treatment was performed for 7 consecutive days.Patients were assessed using VAS,Ramsay sedation scale and Hamilton Depression Rating Scale(HAMD)on postoperative 1 day,3,5 and 7 days.The scores of the above scales at different time points and the adverse reactions during treatment were compared between the 2 groups.Results After treatment,there was no statistically significant difference in VAS scores between the two groups on the 1st day after surgery(P>0.05).The VAS scores of the observation group on day 3,5 and 7 after surgery(4.26±1.20,3.45±1.07,1.76±1.18)were significantly lower than those of the control(5.44±1.52,4.82±1.23,3.14±1.16)(P<0.05).There was no statistically significant difference in Ramsay and HAMD scores between the two groups on the 1st day after surgery(P>0.05).The Ramsay scores(1.98±0.53,2.52±0.43,2.74±0.37)of the observation group were significantly higher than those of the control(1.62±0.49,1.91±0.48,2.21±0.42) on day 3,5 and 7 after surgery(P<0.05),while the HAMD scores(20.47±4.01,15.67±2.32,8.49±1.14)were lower than those of the control(22.88±3.98,17.64±2.48,9.46±1.24)(P<0.05).The adverse reactions of both groups were relatively mild,and no patients discontinued treatment due to drug intolerance.The total incidence of adverse reactions in the observation group was 23.26%,with no significant difference as compared to the control(18.60%)(χ2=0.281,P=0.596).Conclusion Application of carbamazepine combined with diclofenac sodium following surgery for traumatic brain injury can effectively reduce the VAS score.Their the synergistic analgesic efficacy can effectively alleviate the depression.Therefore,their combination has a good safety profile.
Surgery for traumatic brain injuryCarbamazepineDiclofenac sodiumPain
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