Objective To analyze the efficacy and safety of low-dose esketamine combined with sufentanil for postoperative analgesia after laparoscopic myomectomy.Methods A total of 98 patients undergoing laparoscopic myomectomy in the affiliated hospitals of Nanchong Central Hospital from August 2020 to August 2023 were selected and randomized equally into the experimental group and the control group.The patients in the experimental group received low-dose esketamine combined with sufentanil for pain relief,while those in the control group received sufentanil only.The vital signs and pain at 2 h,6 h and 24 h after surgery,the inflammatory stress indexes before surgery and 24 h,and the occurrence of adverse reactions 24 h after surgery were compared between the two groups.Results There was no statistically significant difference in the mean artery pressure and heart rate at 2 h,6 h and 24 h after surgery between the two groups(P>0.05).The scores of visual analogue scale of the 6 h and 24 h of the experimental groups at rest and during activity were(1.94±0.33),(1.35±0.40)and(5.57±0.45),(2.16±0.43),respectively,which were lower than(3.14±0.31),(1.93±0.43)and(6.15±0.55),(3.36±0.52)of the control group(P<0.05).At 24 h after surgery,the serum levels of tumor necrosis factor-α,noadrenaline and interleukin-6 in the experimental group were(15.73±2.08)g·L-1,(704.84±86.32)pmol·L-1 and(46.52±5.28)ng·L-1,respectively,which were lower than(21.18±3.17)g·L-1,(753.21±85.60)pmol·-1L and(53.87±6.26)ng·L-1 of the control group(P<0.05).The incidence of adverse reactions 24 h after operation was lower in the experimental group(4.08%vs.18.37%)(P<0.05).Conclusion Low dose esketamine combined with sufentanil has good analgesic effect after laparoscopic myomectomy.Meanwhile,it can decrease the level of inflammatory stress in the body,has no adverse effects on vital signs and also reduce the risk of adverse reactions.
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