Objective To explore the therapeutic effect of imipenem on acute respiratory distress syndrome caused by sepsis.Methods Ninety-eight patients with acute respiratory distress syndrome caused by sepsis admitted to our hospital from January 2020 to December 2023 were enrolled in this study and randomized into the control group and the observation group.Patients in the control group(n=49)received continuous blood purification,and those in the the observation one(n=49)continuous blood purification and administration of imipenem.The efficacy,changes in inflammatory indicators,Sequential Organ Failure Assessment(SOFA)scores,acute physiological scores and Chronic Health Evaluation System Ⅱ(APACHE Ⅱ)scores were compared between the 2 groups.Results The total effective rate of treatment in the observation group and control group was 91.84%and 77.55%,respectively(P<0.05).After treatment,the white blood cell count(WBC),procalcitonin(PCT),and C-reactive protein(CRP)in the observation group were(8.38±2.17)×109·L-1,(0.29±0.20)μg·L-1,and(7.22±1.97)mg·L-1,respectively,which were all lower than those of(12.57±2.25)×109·L-1,(0.88±0.24)μg·L-1 and(10.15±2.06)mg·L-1 in the control(P<0.05).The SOFA score in the observation group was(4.17±2.00)points and the APACHE Ⅱ score was(7.34±2.19)points,which were lower than those of(7.67±2.04)points and(11.4±2.82)points in the control(P<0.05).Conclusion Imipenem has good therapeutic effect on acute respiratory distress syndrome caused by sepsis because it can better reduce the body's inflammation level and improve the patient's condition.
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