Objective To explore the clinical efficacy and safety of metoprolol combined with radiofrequency ablation in the treatment of arrhythmia cardiomyopathy(AIC)in children.Methods A total of 94 children with AIC admitted to our hospital from January 2021 to January 2022 were selected as subjects and randomized into the control group(radiofrequency ablation treatment,n=47)and study group(metoprolol combined with radiofrequency ablation treatment,n=47).The differences in the curative effect and incidence of adverse reactions were compared between the two groups.Results After treatment,the results in control group and study group such as the left ventricular end diastolic diameter(LVEDD)value(2.60 mm and 1.70 mm),average heart rate(113.61±20.13)beat·min-1 and(101.22±18.72)beat·min-1,fastest heart rate(151.75±27.63)beat·min-1 and(135.22±25.24)beat·min-1,brain-type natriuretic peptide(BNP)elevation rate(44.68%and 12.76%),troponin I elevation rate(23.40%and 10.63%),creatine kinase MB(CK-MB)levels(5.16±0.96)ng·mL-1 and(3.10±1.01)ng·mL-1,and erythrocyte sedimentation rate(ESR)values(11.63±3.96)mm·h-1 and(6.12±2.25)mm·h-1 were significantly lower than those before treatment(P<0.05).The left ventricular ejection fraction(LVEF)and left ventricular shortening fraction(LVFS)in the were(55.89±5.82)%and(64.33±6.11)%in the control group and 29.42%and 32.63%in the study one,which were obvious increased as compared with those before treatment(P<0.05),and all the above indicators were better in the study group than in the control after treatment(P<0.05).There was no difference in the incidence of adverse reactions between the observation group(4.25%)and the control(6.38%).One year and 2 years after treatment,the total effective rates in the study group(78.71%and 91.84%)were lower than those in the control(57.44%and 74.46%),and the readmission rates in the study group(4.25%and 6.38%)were lower than those in the control(23.40%and 31.91%),and the difference was statistically significant(P<0.05).Conclusion Radiofrequency ablation combined with metoprolol improves symptoms and has high safety in the treatment of pediatric AIC.
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