奥司他韦对甲型与乙型流感患儿症状改善及不良反应的影响
Symptomatic improvement and adverse reactions of oseltamivir in treatment of children with influenza A or B
吕晓枝 1孙刚2
作者信息
- 1. 南方医科大学卫生管理学院教研室,广州 510000;中山大学孙逸仙纪念医院临床研究中心,广州 510000
- 2. 南方医科大学卫生管理学院教研室,广州 510000
- 折叠
摘要
目的 探讨奥司他韦对甲型与乙型流行性感冒患儿症状改善及不良反应影响.方法 回顾性选取2020年6月—2022年9月中山大学孙逸仙纪念医院收治的甲、乙型流感患儿81例,根据抗原检测结果分为甲型流感组(47例)与乙型流感组(34例).两组患儿均采用磷酸奥司他韦治疗,对比观察两组患儿的症状改善时间、临床疗效以及不良反应发生情况.结果 甲型流感组患儿高热、咳嗽、鼻塞流涕、全身症状改善时间分别为(1.62±0.53)d、(3.20±0.75)d、(4.08±1.24)d、(4.10±1.26)d,乙型流感组患儿分别为(3.47±0.78)d、(4.61±1.35)d、(5.11±1.27)d、(5.56±1.50)d,甲型流感组症状改善时间均短于乙型流感组(均P<0.05).甲型流感组治疗有效率(95.74%,45/47)高于乙型流感组(82.35%,28/34)(P<0.05),甲型流感组不良反应发生率与乙型流感组比较差异无统计学意义[10.63%(5/47),11.67%(4/34),P>0.05].结论 奥司他韦对甲型与乙型流感患儿治疗均有效,不良反应发生情况较少.奥司他韦治疗甲型流感患儿的效果以及症状改善情况均优于乙型流感患者.
Abstract
Objective To explore the symptomatic improvement and adverse effects of oseltamivir in the treatment of children with influenza A or B.Methods The clinical data of 81 children with influenza admitted to Sun Yat-sen Memorial Hospital,Sun Yat-sen University from June 2020 to September 2022 were retrospectively analyzed.The 81 children were classified into influenza A group(n=47)and influenza B group(n=34)according to antigen detection results.All children were treated with oseltamivir phosphate,then the symptom improvement time,clinical efficacy and occurrence of adverse reactions were compared between the 2 groups.Results The time to improvement of high fever,cough,nasal congestion and runny nose,and systemic symptoms was(1.62±0.53)d,(3.20±0.75)d,(4.08±1.24)d,and(4.10±1.26)d respectively in influenza A group,which were all shorter than those of influenza B group((3.47±0.78)d,(4.61±1.35)d,(5.11±1.27)d,and(5.56±1.50)d),showing statistical difference(all P<0.05).The clinical efficacy rate in influenza A group(95.74%,45/47)was higher than that in the influenza B group(82.35%,28/34)(P<0.05).There was no statistically significant difference in adverse reaction rate between the two groups(10.63%(5/47),11.67%(4/34),P>0.05).Conclusion Oseltamivir is effective in treating both influenza A and B in children with fewer adverse effects.And it is more effective in treating children with influenza A than the those with influenza B in terms of clinical symptom improvement.
关键词
甲型流感/乙型流感/奥司他韦/临床疗效/不良反应/儿童Key words
Influenza A/Influenza B/Oseltamivir/Clinical efficacy/Adverse reaction/Children引用本文复制引用
基金项目
广东省哲学社会科学规划一般项目(2023)(GD23CGL11)
出版年
2024
NETL
NSTL
万方数据