降钙素原、血乳酸对脑膜炎患儿美罗培南治疗预后的预测作用
Predictive value of procalcitonin and lactic acid for prognosis of purulent meningitis treated with meropenem in children
张清雯 1兰俊 1王辉 1宋坤泽1
作者信息
- 1. 三二〇一医院微生物免疫科,汉中 723000
- 折叠
摘要
目的 探究血清中降钙素原(PCT)、血乳酸(Lac)水平与化脓性脑膜炎患儿美罗培南治疗效果的关系.方法 选取2021年10月—2023年9月化脓性脑膜炎患儿54例,于入院时行血清PCT和Lac表达检测,给予美罗培南治疗28 d,治疗结束后根据不同预后情况进行分组.分析PCT和Lac水平与疾病严重程度的关系以及对美罗培南治疗效果的预测价值.结果 重度患者PCT为(21.44±1.35)ng·L-1,Lac为(2.69±0.51)mmol·L-1,均高于中度和轻度患者(P<0.05).Pearson相关性分析发现,化脓性脑膜炎患儿血清PCT、Lac表达和疾病严重程度呈正相关(P<0.05).54例患儿中预后良好41例,预后不良13例.预后不良组PCT为(24.84±1.23)ng·L-1,Lac为(2.84±0.43)mmol·L-1,高于预后良好组(P<0.05).ROC曲线分析显示,血清PCT、Lac表达预测患儿预后的AUC分别为0.824、0.682,两者联合预测效能更高.结论 血清PCT和Lac水平与化脓性脑膜炎患儿疾病严重程度呈正相关,其对美罗培南治疗患儿的预后有一定的预测价值.
Abstract
Objective To investigate the correlation of serum procalcitonin(PCT)and lactic acid(Lac)concentration with the therapeutic efficacy of meropenem in treatment of purulent meningitis in children.Methods Fifty-four children with purulent meningitis treated in our hospital from October 2021 to September 2023 were selected and subjected to the test of serum PCT and Lac concentration.Children were given meropenem for 28 d,and grouped according to different prognoses.Then the correlation of PCT and Lac concentration with the severity of the disease was identified,and their predictive value for the therapeutic efficacy of meropenem was determined.Results PCT and Lac concentrations were(21.44±1.35) ng·L-1 and(2.69±0.51) mmol·L-1 in severe patients,which were higher than those in moderate and mild ones(P<0.05).Pearson's correlation analysis revealed a positive correlation between serum PCT,Lac concentration and disease severity in children with purulent meningitis(P<0.05).Of the 54 children,41 had a good prognosis and 13 a poor one.PCT and Lac concentrations were(24.84±1.23) ng·L-1 and(2.84±0.43) mmol·L-1 in poor prognosis group,which were higher than those in good prognosis group(P<0.05).ROC curve analysis showed that the AUCs of serum PCT and Lac for predicting the prognosis of children were 0.824 and 0.682,and the combined test of the two had better predictive efficacy.Conclusion Serum PCT and Lac concentrations are positively correlated with disease severity in children with purulent meningitis and are of certain value in predicting the therapeutic efficacy of meropenem in children.
关键词
化脓性脑膜炎/美罗培南/降钙素原/血乳酸/预后Key words
Purulent meningitis/Meropenem/Procalcitonin/Lactic acid/Prognosis引用本文复制引用
出版年
2024
NETL
NSTL
万方数据