Objective To assess the therapeutic efficacy and safety of a combination treatment consisting of minocycline hydrochloride ointment and PVP-I for patients suffering from chronic periodontitis.Methods A total of 106 patients with chronic periodontitis treated in Tianjin Children's Hospital from August 2019 to March 2022 were enrolled and randomized into experimental group and control group.The 60 patients in the experimental group received therapy with both minocycline hydrochloride ointment and PVP-I.Concurrently,the 46 patients in the control one received treatment with minocycline hydrochloride ointment alone.Then the efficacy of the treatments in both groups was evaluated and compared.Results The combined response rate for the experimental group reached 95.0%,outperforming the 78.3%rate seen among the control participants.This variance was statistically notable(χ2=5.314,P=0.021).After treatment,the experimental group displayed an oral health score of 8.9±1.1,which showed a substantial decrease from the control group's score of 16.8±2.0(t=25.928,P<0.001).Furthermore,the experimental group showed improvements in various periodontal indices.The SBI,PD,CAL and PLI were all lower in the experimental group(1.1±0.1,2.1±0.2,2.6±0.2,1.8±0.2 mm,respectively)than those in the control[(2.4±0.2,3.8±0.4,3.2±0.3,2.8±0.3 mm,respectively)(t=28.661,43.759,12.332,20.554,all P<0.001)],confirming the statistical significance of the differences.Regarding adverse reactions,there was no notable discrepancy between the experimental group(3.4%)and the control(4.3%)(χ2=0.133,P=0.715).Conclusion The use of minocycline hydrochloride ointment combined with PVP-I demonstrates enhanced effectiveness in the treatment of chronic periodontitis without an elevated risk of adverse reactions.It can remarkably improve the prognosis in patients,warranting further investigation of larger clinical samples.
NETL
NSTL
万方数据
