Objective To investigate the distribution characteristics of pathogenic bacteria in traumatic endophthalmitis and the in vitro sensitivity of major drug-resistant staphylococcus aureus to commonly used ophthalmic antibiotics.Methods A total of 136 bacterial strains detected from the patients with traumatic endophthalmitis at Mianyang Central Hospital from July 2018 to July 2023 were collected for bacterial culture,identification,and drug sensitivity test.Results Of the 136 strains,81 strains were gram-positive bacteria,49 strains were gram-negative bacteria and 6 strains were fungi.The main pathogenic bacteria were 42 strains of staphylococcus aureus and 18 strains of staphylococcus epidermidis.The minimum inhibitory concentration(MIC)differences of the two drug-resistant staphylococcus species to levofloxacin,cefazolin sodium,tobramycin and fusidic acid were relatively low(ranging from 0.7 to 7.5 μg·mL-1),while the difference in the MIC to clindamycin was significant(ranging from 2.5 to 500 μg·mL-1).There was no statistically significant difference in the sensitivity of drug-resistant staphylococcus species to the five antibiotics(P>0.05).However,there were statistically significant differences in the sensitivity rates of the drug-resistant staphylococcus species to the five ophthalmic antibiotics(P<0.05).Specifically,the sensitivity rates of the drug-resistant staphylococcus species to cefazolin sodium and fusidic acid were significantly higher than those to clindamycin,levofloxacin and tobramycin.Conclusion Drug-resistant staphylo-coccus aureus is the main pathogenic bacterium in patients with traumatic endophthalmitis.The antibacterial activities of fusidic acid and cefazolin sodium against drug-resistant staphylococcus aureus are superior to those of tobramycin,levofloxacin and clindamycin.
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