Pharmaceutical practice of clinical pharmacists participating in anticoagulant therapy of a patient with thrombotic antiphospholipid syndrome combined with cerebral infarction
A 29-year-old young man was admitted due to"numbness and weakness in the right upper limb for over a month,and headache and neck pain for a week".Head MRI suggested cerebral infarction.The patient was treated with antiplatelet therapy according to the treatment principle of cerebral infarction after admission.The patient was diagnosed with thrombotic antiphospholipid syndrome and changed to warfarin anticoagulant therapy.During anticoagulant therapy,the international normalized ratio of warfarin of patients failed to be quickly and stably within a reasonable treatment range,and an appropriate warfarin maintenance dose could not be found.Therefore,clinical pharmacists recommended to conduct warfarin gene test.Based on the individual conditions of patients and gene test results,the clinical pharmacists calculated the reasonable maintenance dose of warfarin through the Accurate Medication Model(IWPC model)and formulated the medication adjustment plan,and conducted medication monitoring during the anticoagulation process.Eventually,the patient recovered after treatment with this anticoagulant regimen.
Antiphospholipid syndromeCerebral infarctionWarfarin anticoagulantDrug genesPrecision drug useMedication managementClinical pharmacist
NETL
NSTL
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