Analysis of incidence and risk factors of acute myelosuppression in patients with esophageal cancer during radiotherapy combined with Tegio administration
Objective To investigate the incidence of acute myelosuppression and its influencing factors during radiotherapy combined with tegafur treatment in patients with esophageal cancer.Methods Clinical data of 60 patients with esophageal cancer who received radiotherapy combined with tegafur treatment in Fuyang Tumor Hospital from January 2019 to January 2024 were retrospectively analyzed.Univariate analysis was used to screen potential factors related to acute myelosuppression during the treatment,and multivariate Logistic regression analysis was conducted to determine the independent risk factors for acute myelosuppression.Results Univariate analysis showed that the proportions of white blood cell(WBC)count≤3.0×109·L-1,hemoglobin(Hb)≤100 g·L-1,neutrophils≤2.0×109·L-1,and hematocrit≤37%were higher in the myelosuppression group than in the non-myelosuppression group(P<0.05).Multivariate Logistic regression analysis indicated that increased levels of WBC,Hb,and neutrophils were protective factors against acute myelosuppression during the treatment(P<0.05).Conclusion There is a high incidence of acute myelosuppression during radiotherapy combined with tegafur treatment in esophageal cancer,which is associated with multiple factors.Clinically,individual patient conditions and risk factors should be assessed to choose appropriate treatment plans.Routine blood parameters should be monitored promptly to prevent and manage acute myelosuppression and its complications,thereby improving the quality of life and treatment outcomes of the patients.
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