Efficacy of calcitriol capsule combined with dapagliflozin in treatment of diabetic nephropathy
Objective To investigate the clinical efficacy of calcitriol capsule combined with dapagliflozin in treatment of diabetic nephropathy(DN).Methods A total of 186 patients with DN admitted to The First Affiliated Hospital of Henan University from June 2022 to November 2023 were enrolled in this study and randomized into the study group and control group,with 93 in each group.The patients in the control group were treated with dapagliflozin while those in the study one with calcitriol capsule in addition to dapagliflozin.The clinical efficacy,blood glucose profile,renal function and hypersensitive C-reactive protein were compared between the 2 groups after treatment.Results Study group reported a higher clinical efficacy rate as compared with the control(92.47%vs 79.57%,P<0.05).The levels of 2-hour blood glucose,glycated haemoglobin and fasting blood glucose were decreased in all the patients after treatment.These indexes in the study group were significantly lower than those in the control((8.04±1.27) mmol·L-1 vs(8.63±1.33) mmol·L-1,(6.31±1.19)%vs(7.26±1.22)%,(6.27±1.30) mmol·L-1 vs(7.04±1.69) mmol·L-1,all P<0.05).Meanwhile,the levels of blood urea nitrogen,serum creatinine,24-hour urine protein and cystatin C showed a decrease in all patients after treatment.They were significantly lower in the study group than those in the control group((5.03±1.23) mmol·L-1 vs(5.71±1.30) mmol·L-1,(208.43±23.19) μmol·L-1 vs(220.25±23.24) μmol·L-1,(1.14±0.20) g vs(1.76±0.22) g,(1.01±0.18) mg·L-1 vs(1.27±0.25) mg·L-1,P<0.05).Serum levels of hypersensitive C-reactive protein showed a decrease in all patients after treatment,which was lower in the study group than in the control((1.78±0.34) mg·L-1 vs(3.14±0.52) mg·L-1,P<0.05).Conclusion The application of calcitriol capsule combined with dapagliflozin in the treatment of diabetic nephropathy has significant therapeutic effect because it can effectively regulate the blood glucose profile,inhibit urine albumin excretion,improve renal function and attenuate inflammatory response in patients.
DiabetesNephropathyCalcitriol capsuleDapagliflozinBlood sugarKidney function
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