Objective To investigate the placental perfusion and safety profile of magnesium sulfate injection in the adjuvant treatment of preeclampsia.Methods Eighty-two patients with preeclampsia adimitted to the Affiliated Jianhu Hospital of Xinglin Colleg of Nantong University from September 2020 to September 2023 were enrolled in this study and grouped using random number table method,with 41 in each group.The patients in the control group received conventional symptomatic treatment in combination with magnesium sulfate.Based on this treatment regimen,those patients in the observation group recieved labetalol in addition.Then the clinical efficacy,placental perfusion indices(resistance index(RI),systolic/diastolic(S/D)ratio,pulsatility index(PI)),blood pressure,24-h urine protein,adverse pregnancy outcomes and incidence of adverse reactions were compared between the two groups.Results The observation group reported a higher clinical efficacy rate as compared with the control group(90.24%vs 73.17%,χ2=3.998,P<0.05).A decrease in RI,S/D and PI was observed in all patients after treatment,and the reduction was more notable in the observation group than in the control((0.49±0.05)scores vs(0.56±0.07)scores,(2.51±0.32)scores vs(2.83±0.35)scores,(0.84±0.07)scores vs(0.92±0.08)scores,t=5.210,4.321,4.819,all P<0.05).Systolic blood pressure,diastolic blood pressure and 24-h urine protein were decreased in both groups,and they were remarkably lower in the observation group than in the control((136.32±9.85)mm Hg vs(142.54±9.08)mm Hg,(101.51±7.32)mm Hg vs(108.83±7.34)mm Hg,(3.84±1.27)g vs(5.92±1.78)g,t=2.973,4.522,6.091,all P<0.05).The observation group yielded lower rate of adverse maternal outcomes(7.32%vs 24.39%)and adverse neonatal outcomes(12.2%vs 31.71%),(χ2=4.479,4.556,both P<0.05).The 5-min Apgar score was significantly higher in the observation group than in the control((8.21±0.81)scores vs(7.84±0.82)scores,χ2=4.479,4.556,t=2.056,all P<0.05).There was no statistically significant difference in the incidence of adverse events between the two groupss(χ2=0.945,P>0.05).Conclusion Being used in conjunction with labetalol to treat preeclampsia,magnesium sulfate injection can safely lower the placental perfusion and avoid the risk of unfavorable pregnancy outcomes.
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