Therapeutic efficacy of hyperbaric oxygen combined with sertraline in treatment of depression and its impact on serum levels of DA and 5-HT in patients after traumatic brain injury
Objective To investigate the therapeutic efficacy of hyperbaric oxygen combined with sertraline in treatment of depression and its impact on serum levels of dopamine(DA)and 5-hydroxytryptamine(5-HT)in patients after traumatic brain injury.Methods A total of 102 patients with post-traumatic brain injury depression admitted to Shiyan People's Hospital from January 2021 to January 2023 were enrolled in this study and randomized into the control group(n=51)and study group(n=51).The patients in the control group were treated with sertraline,whereas those in the study group were treated with sertraline combined with hyperbaric oxygen.Then the Barthel index(BI),serum DA,5-HT,Hamilton rating scale for depression(HAMD)and Loewenstein Occupational Therapy Cognitive Assessment(LOTCA)were compared between the two groups.Results After 4 weeks of treatment,the BI score of the study group was higher than that of the control((89.56±5.90) points,(76.89±3.27) points,P<0.05),and the levels of DA((79.66±30.89) nmol∙L-1,(62.58±20.52) nmol∙L-1)and 5-HT((479.85±219.52) ng∙mL-1,(364.14±200.41) ng∙mL-1)of the study group were higher than those of the control(both P<0.05).The HAMD score of the study group was lower than that of the control(P<0.05),and the LOTCA scores in all dimensions were higher than those of the control(all P<0.05).Conclusion Hyperbaric oxygen therapy combined with sertraline can alleviate depressive behavior in patients and improve their cognitive function,which may be related to the upregulation of serum DA and 5-HT levels.
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