A study on correlation between plasma concentration of imrecoxib and adverse drug reactions in patients with knee osteoarthritis
Objective To explore the correlation between blood drug concentration and adverse drug reaction(ADR)of imrecoxib in the treatment of knee osteoarthritis.Methods The clinical data of 124 patients receiving imrecoxib therapy for knee osteoarthritis who were routinely monitored in the Third People's Hospital of Hubei Province and Hanchuan People's Hospital from March 2020 to September 2023 were retrospectively analyzed.Patients were divided into the ADR group(n=30)and non-ADR group(n=94)according to the occurrence of ADR.The correlation between plasma concentration of imrecoxib and ADR occurrence in all the patients was investigated.Logistic regression analysis was used to identify the risk factors of ADR.Results The levels of aspartate aminotransferase(AST),blood urea nitrogen(BUN)and steady state trough concentration(Cssmin)in the ADR group were(21.58±3.21)U·L-1,(5.32±0.51)mmol·L-1 and(46.57±15.98)μg·L-1,respectively,which were higher than those of((19.93±3.11)U·L-1,(5.07±0.58)mmol·L-1 and(37.39±9.75)μg·L-1)in the non-ADR group(all P<0.05).Cssmin for gastrointestinal reactions,lower limb edema and rash was(40.13±10.98)U·L-1,(37.94±6.31)mmol·L-1 and(35.67±4.35)μg·L-1,which was higher than that of((19.93±3.11)U·L-1,(5.07±0.58)mmol·L-1 and(37.39±9.75)μg·L-1)in those patients without the disease(all P<0.05).AST,BUN and Cssmin of imrecoxib were risk factors for ADR(OR=1.642,1.487,2.365,95%CI=1.241-2.173,1.185-1.867,1.598-3.501,all P<0.05).Conclusion The incidence of ADR in patients gradually increases as the level of Cssmin is elevated.AST,BUN and Cssmin are risk factors for the occurrence of ADR.
Knee osteoarthritisImrecoxibDrug monitoringPlasma drug concentrationAdverse drug reaction
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