Effect of tranexamic acid on coagulation and hand function after surgery for hand fracture
Objective To investigate the effect of tranexamic acid on coagulation and hand function after hand fracture surgery.Methods Sixty-four patients undergoing hand fracture surgery in People's Hospital of Leshan from May 2021 to July 2023 were selected,and randomly grouped using lottery method,with 32 in each group.The patients in the control group were given intravenous drip of 100 mL sodium chloride 30 min before operation,and those in the observation one intravenous injection of 100 mL of sodium chloride+tranexamic acid 30 min before operation.The total blood loss,coagulation function,hand function and adverse reactions were compared between the 2 groups.Results Perioperative total blood loss was(57.39±9.68) mL in the observation group and(103.28±14.97)mL in the control,showing statistical difference(P<0.05).There was no statistical difference in prothrombin time(PT),activated partial thromboplastin time(APTT),and D-dimer(D-D)at baseline between the 2 groups before and after operation(P>0.05).The differences in pre-and post-treament manual muscle testing(MMT)((1.57±0.19),(2.14±0.22)scores,separately)and Fugl-Meyer assessment(FMA)((4.28±1.06),(5.37±1.27)scores,separately)demonstrated statistical difference between the two groups(t=11.092,P<0.05;t=3.727,P<0.05).The total adverse reaction rate was 3.13%in the control group,which was slightly lower than 6.25%of the observation group,demonstrating no statistical difference(P>0.05).Conclusion Preoperative application of tranexamic acid can effectively reduce perioperative blood loss in patients undergoing hand fracture surgery without affecting coagulation function.Meanwhile,it can promote the recovery of hand function after surgery.
Hand fracture surgeryTranexamic acidCoagulation functionHand functionBlood loss
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