Efficacy of nicotinamide injection combined with ticagrelor in patients undergoing percutaneous coronary intervention for acute myocardial infarction
Objective To observe the efficacy of nicotinamide injection combined with ticagrelor in patients receiving percutaneous coronary intervention for acute myocardial infarction.Methods A total of 86 patients with acute myocardial infarction admitted to Tangshan Hongzi Hospital from May 2022 to December 2023 were included in the study and grouped by random number table method.All patients received percutaneous coronary intervention,and were treated with ticagrelor after surgery in the control group(n=43),and niacinamide injection combined with ticagrelor in the observation group(n=43).The efficacy,the incidence of cardiovascular adverse events and adverse drug reactions,the changes of left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVDD)and stroke output(SV),and the changes of nitric oxide(NO)and endothelin-1(ET-1)levels were compared between the two groups.Results The total effective rate of the observation group(95.35%)was higher than that of the control(81.40%)(χ2=4.074,P<0.05).The incidence of adverse cardiovascular events in the observation group(4.65%)was lower than that of the control(18.60%)(χ2=4.074,P<0.05).The adverse drug reaction rates in the observation group and the control group were 6.98%and 4.65%,respectively(χ2=0.212,P>0.05).After treatment,the cardiac function indexes of LVEF,LVDD and SV in the observation group were(53.27±3.22)%,(43.26±3.09)mm and(85.45±2.95)mL·min-1,respectively,which were higher than those in the control((46.56±3.16)%,(49.65±4.11)mm,(77.65±4.04)mL·min-1,t=9.753,8.149,10.225,all P<0.05).After treatment,NO and ET-1 levels of the observation group were(62.46±3.05)μmol·L-1 and(4.04±0.39)ng·mL-1,respectively,which were better than those of the control((50.45±2.52)μmol·L-1 and(5.29±0.54)ng·mL-1,t=19.906,12.306,both P<0.05).Conclusion The application of nicotinamide injection combined with ticagrelor in acute myocardial infarction after PCI surgery can effectively improve the cardiac function of patients and reduce the incidence of cardiovascular adverse events and adverse drug reactions.
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