Influence of Shengxuening combined with roxadustat on anemia indicators and serum levels of iron and ferritin in patients with renal anemia due to chronic kidney disease
Objective To explore the clinical efficacy of Shengxuening combined with roxadustat in treatment of renal anemia(RA)due to chronic kidney disease and analyze its influence on anemia indicators and serum levels of iron and ferritin.Methods A total of 82 patients with RA due to chronic kidney disease admitted to Huainan First People's Hospital from January 2023 to September 2023 were selected as the subjects,and divided into the combined group(n=41)and single group(n=41)according to the random envelope method.The patients in the control group were treated with roxadustat while those in the the combined group with Shengxuening tablets in addition to roxadustat.The therapeutic efficacy,anemia indicators(hemoglobin(Hb),hematocrit(Hct)),iron metabolism indicators(serum iron(SI),serum ferritin(SF),transferrin saturation(TSAT)),lipid metabolism indicators(total cholesterol(TC),low density lipoprotein(LDL),high density lipoprotein(HDL))and occurrence of adverse reactions were compared between the two groups.Results The total effective rate of clinical treatment in the combined group was 95.12%,which was higher than that of 75.61%in the single group(χ2=6.248,P<0.05).After treatment,the levels of Hb,Hct,SI,SF and TSAT were(103.46±18.84)g·L-1,(33.29±6.52)%,(17.79±4.63)μmol·L-1,(211.14±44.10)ng·mL-1 and(31.80±7.84)%in the combined group,which were higher than those of(92.51±16.92)g·L-1,(29.76±6.08)%,(14.26±3.36)μmol·L-1,(185.03±54.14)ng·mL-1 and(27.80±7.99)%in the single group(t=2.798,2.535,3.951,2.394,2.288,all P<0.05).There were no statistical differences in levels of TC,LDL and HDL between the two groups after treatment(t=0.477,0.251,0.309,all P>0.05).The total incidence rate of adverse reactions was no significant difference between the two groups(P>0.05).Conclusion The application of Shengxuening combined with roxadustat can enhance the clinical efficacy and effectively improve the anemia in patients with RA due to chronic kidney disease.
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