Objective To investigate the efficacy of magnesium isoglycyrrhizinate injection in treatment of liver malignant tumor and its effect on liver function and inflammatory factors.Methods A total of 98 patients with liver malignant tumor admitted to Taihe County Hospital of Traditional Chinese Medicine affiliated to Anhui University of Chinese Medicine from January 2022 to January 2024 were enrolled in this study and divided into two groups by random number table method.All patients received transcatheter arterial chemoembolization(TACE)treatment.The patients in the control group(n=49)were treated with reduced glutathione injection after surgery while those in the observation group(n=49)with reduced glutathione injection and magnesium isoglycyrrhizinate injection after surgery for 10 days.The clinical curative effect,the incidence of liver injury,adverse reactions,serum levels of tumor necrosis factor Alpha(TNF-α),interleukin-6(IL-6)and AFP were compared between the two groups.Results The total effective rate was 71.43%in the observation group and 63.27%in the control(χ2=0.742,P>0.05),showing no statistical significance.The incidence of liver injury in the observation group(28.57%)was lower than that in the control(59.18%)(χ2=9.324,P<0.05).The adverse reaction rate was 2.04%in the observation group and 4.08%in the control(χ2=0.344,P>0.05),demonstrating no statistical significance.After treatment,the serum levels of TNF-α and IL-6 in the observation group were(41.25±4.23)μg·mL-1 and(35.49±5.23)μg·mL-1,respectively,which were lower than those of(69.23±6.62)μg·mL-1 and(57.73±4.23)μg·mL-1 in the control(t=24.931,48.908,both P<0.05).The AFP level in the observation group was(77.63±6.93)pg·mL-1,which was lower than that of(122.65±9.54)pg·mL-1 in the control(t=26.726,P<0.05).Conclusion Magnesium isoglycyrrhizinate injection can better protect the liver function of patients with liver malignant tumor treated by TACE,inhibit the tumor to a certain extent and improve the therapeutic effect.This treatment is safe and reliable and can be used for the improvement of the patient's condition.
Liver malignant tumorMagnesium isoglycyrrhizinate injectionLiver functionTherapeutic efficacyTumor markerAdverse drug reaction
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