Relationship between serum vancomycin concentration change level and therapeutic effect of acute kidney injury in septic shock neonates
Objective To explore the relationship between vancomycin plasma concentration changes,efficacy or acute kidney injury(AKI)in neonatal septic shock.Methods A total of 102 neonates with septic shock who were admitted to the Department of Pediatrics,Xinxiang Central Hospital from December 2020 to December 2023 were retrospectively included in the study.The basic information and related indicators of the patients were collected.The mean serum steady-state valley concentration(Cmin)of vancomycin was recorded when the serum concentration reached stable state.Patients were divided into<10 mg·L-1 group,10-15 mg·L-1 group and>15 mg·L-1 group according to the mean Cmin value.To explore the clinical efficacy and incidence of AKI in children with different Cmin groups of vancomycin.Results AKI occurred in 34 of 102 children,with an incidence of 33.33%.The difference in AKI incidence among the three groups was statistically significant(χ2=9.280,P=0.010).Of the 102 children,75 were effective and 27 were ineffective,and the clinical effective rate was 73.53%(75/102).There was no significant difference in the clinical effective rate among the three groups(χ2=0.924,P=0.630).Conclusion There was no significant relationship between vancomycin Cmin and the therapeutic effect of neonatal septic shock.There is a certain relationship between Cmin and the incidence of AKI,and the incidence of AKI is the highest when the average Cmin is greater than 15 mg·L-1.
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